Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Abstract

The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

“…It is widely accepted that herbal products are superior to synthetic pharmaceuticals owing to the broad availability of herbal products as well as the great amount of empirical and readily available evidence about their traditional usage [ 31 – 35 ]. Modern scientific techniques, on the other hand, should be used to verify the claims made regarding the medicinal properties of plants, which would result in validation of the traditional system of medicine [ 36 – 38 ].…”

In Vitro Alpha-Amylase Enzyme Assay of Hydroalcoholic Polyherbal Extract: Proof of Concept for the Development of Polyherbal Teabag Formulation for the Treatment of Diabetes

“…In both traditional and contemporary medicine, plants constitute an important source of bioactive chemicals that contribute to the prevention and treatment of disease. Plant-derived products have long been utilized by people all over the world to treat various ailments [ 28 – 30 ]. After going through the above literature, we have designed a work to formulate a polyherbal teabag for the treatment of diabetes mellitus.…”

Analysis on Acupoint Selection and Combination for Amyotrophic Lateral Sclerosis Treated with Acupuncture Based on Data Mining

“…Through the ages, people have realized the curative benefits of natural products. Several ethnomedicinal herbs have been promoted to equip a neurobehavioral state and operate as a complement to modern medications [ 9 , 10 ]. In addition to improving physical conditions [ 11 ], these natural bioactive compounds play an active modulatory role in the pathological molecular mechanisms of neurodegenerative disorder development [ 12 , 13 ], such as ALS, with the potential neuroprotective pharmaceutical value [ 14 ].…”