The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

Maffei, Margherita; Barone, Ilaria; Scabia, Gaia; Santini, Ferruccio

doi:10.1210/er.2016-1009

Cited by 53 publications

(56 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is induced by inflammatory stimuli and repressed by PPAR-γ. Mice lacking haptoglobin have increased adiponectin and are protected from HFD-induced metabolic dysfunction but have muscle atrophy 122 . Saturated fatty acids increase haptoglobin gene expression in murine adipose tissue 123 .…”

Section: Macrophage and Adipocyte Dysfunction In Obese Adipose Tissuementioning

confidence: 99%

Macrophage functions in lean and obese adipose tissue

2017

View full text Add to dashboard Cite

Summary Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes.

show abstract

Section: Macrophage and Adipocyte Dysfunction In Obese Adipose Tissuementioning

confidence: 99%

Macrophage functions in lean and obese adipose tissue

2017

View full text Add to dashboard Cite

show abstract

“…The level of haptoglobin and lipocalin, which are considered markers of both inflammation and adiposity [18,19], was measured. As shown in Figure 5, no diet-associated variation of lipocalin concentration was detected in plasma, hippocampus or cortex, while in e-WAT lipocalin protein content significantly increased in HFF rats.…”

Section: Inflammatory Markersmentioning

confidence: 99%

Adipose Tissue and Brain Metabolic Responses to Western Diet—Is There a Similarity between the Two?

Mazzoli

Spagnuolo

Gatto

et al. 2020

IJMS

View full text Add to dashboard Cite

Dietary fats and sugars were identified as risk factors for overweight and neurodegeneration, especially in middle-age, an earlier stage of the aging process. Therefore, our aim was to study the metabolic response of both white adipose tissue and brain in middle aged rats fed a typical Western diet (high in saturated fats and fructose, HFF) and verify whether a similarity exists between the two tissues. Specific cyto/adipokines (tumor necrosis factor alpha (TNF-α), adiponectin), critical obesity-inflammatory markers (haptoglobin, lipocalin), and insulin signaling or survival protein network (insulin receptor substrate 1 (IRS), Akt, Erk) were quantified in epididymal white adipose tissue (e-WAT), hippocampus, and frontal cortex. We found a significant increase of TNF-α in both e-WAT and hippocampus of HFF rats, while the expression of haptoglobin and lipocalin was differently affected in the various tissues. Interestingly, adiponectin amount was found significantly reduced in e-WAT, hippocampus, and frontal cortex of HFF rats. Insulin signaling was impaired by HFF diet in e-WAT but not in brain. The above changes were associated with the decrease in brain derived neurotrophic factor (BDNF) and synaptotagmin I and the increase in post-synaptic protein PSD-95 in HFF rats. Overall, our investigation supports for the first time similarities in the response of adipose tissue and brain to Western diet.

show abstract

“…The novel finding that Saa3 and Hp mRNAs were more up-regulated in the KO genotype after LPS suggests that Zip14 expression influences production of these acute phase proteins which appear to have specific roles in skeletal muscle during inflammation. For example, the increased haptoglobin (Hp) may limit muscle atrophy and oxidant defense 45,46 . Saa3 is up-regulated in skeletal muscle by LPS 47 and enhanced induction of Saa3 in the KO mice may be a reflection of muscle degradation/remodeling 48 .…”

Section: Discussionmentioning

confidence: 99%

Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7

Kim

Aydemir

Jimenez

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of skeletal muscle from global Zip14 knockout (KO) and wild-type mice (WT). At basal steady state Zip14 Ko mice exhibited a phenotype that included muscle wasting and metabolic endotoxemia. Microarray and qpcR analysis of gastrocnemius muscle RnA revealed that ablation of Zip14 produced increased muscle p-Mef2c, Hspb7 and miR-675-5p expression and increased p38 activation. chip assays showed enhanced binding of nf-κβ to the Mef2c promoter. in contrast, LpSinduced systemic inflammation enhanced Zip14-dependent zinc uptake by muscle, increased expression of Atrogin1 and MuRF1 and markedly reduced MyoD. these signatures of muscle atrophy and cachexia were not influenced by Zip14 ablation, however. LpS-induced miR-675-3p and-5p expression was Zip14-dependent. Collectively, these results with an integrative model are consistent with a Zip14 function in skeletal muscle at steady state that supports myogenesis through suppression of metabolic endotoxemia and that Zip14 ablation coincides with sustained activity of phosphorylated components of signaling pathways including p-Mef2c, which causes Hspb7-dependent muscle wasting.

show abstract

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

Cited by 53 publications

References 112 publications

Macrophage functions in lean and obese adipose tissue

Macrophage functions in lean and obese adipose tissue

Adipose Tissue and Brain Metabolic Responses to Western Diet—Is There a Similarity between the Two?

Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7

Contact Info

Product

Resources

About