The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS)

Clemens, J. Quentin; Kutch, Jason J.; Mayer, Emeran A.; Naliboff, Bruce D.; Rodríguez, Larissa V.; Klumpp, David J.; Schaeffer, Anthony J.; Kreder, Karl J.; Clauw, Daniel J.; Harte, Steven E.; Schrepf, Andrew; Williams, David A.; Andriole, Gerald L.; Lai, H. Henry; Buchwald, Dedra; Lucia, M. Scott; Bokhoven, Adrie van; Mackey, Sean; Moldwin, Robert; Pontari, Michel A.; Stephens‐Shields, Alisa J.; Mullins, Chris; Landis, J. Richard

doi:10.1002/nau.24423

Cited by 22 publications

(36 citation statements)

References 29 publications

(35 reference statements)

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“…Some women with endometriosis may not complain of CPP at all [8,28,29]. Other chronic pain conditions such as IBS or painful bladder syndrome may be responsible for CPP [30] despite the presence or absence of endometriosis, and women with and without endometriosis in our cohort had a similar incidence of IBS. The much higher rate (double) of depression and higher rate of anxiety reported by women with endometriosis than those women who did not have endometriosis in our cohort also confirm previous reports [12,[31][32][33].…”

Section: Discussionmentioning

confidence: 64%

Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study

Tempest

Efstathiou

Petros

et al. 2020

JCM

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Chronic pelvic pain (CPP) is one of the most common chronic pain problems experienced by women, with prevalence rates comparable to asthma and back pain. However, it is poorly understood and causative pathology is only seldom found. We aimed to establish prevalence of abnormal findings at diagnostic laparoscopy in young women with CPP after normal findings at clinical examination and pelvic ultrasound scan. Information was retrospectively collected on all laparoscopies undertaken on women aged 16–30 years with normal preoperative findings over a 24-month period. One-hundred-and-fifty women (mean age 25 years and BMI 24.5) were included with laparoscopic examination revealing normal anatomy in 110 (73.3%) and pathology in 40 (27.2%). Endometriosis was detected in 30 (20%); 25 (16.7%) stage 1, 2 (1.3%) stage 2, 2 (1.3%) stage 3 and 1 (0.7%) stage 4. Most laparoscopies carried out on young women with CPP and normal clinical examination and pelvic ultrasound scan showed no significant clinical stigmata of pelvic disease. Women should be fully informed of the multifactorial nature of CPP and there should be a comprehensive management pathway for these women, as proceeding with invasive laparoscopy does not provide additional benefit when investigating CPP in the context of risk, cost and effect on long-term wellbeing.

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Section: Discussionmentioning

confidence: 64%

Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study

Tempest

Efstathiou

Petros

et al. 2020

JCM

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“…Biomarkers, distributing across these systems, constituted complex biological networks. The acquisition of biomarkers required a comprehensive biological network-based analysis of fatigue biology (Klimas et al, 2012). In addition, molecular aberrations observed in many CFS blood cell studies provided an opportunity to develop diagnostic analysis of blood samples.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue

et al. 2020

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Background: Fatigue, as a complex, multidimensional symptom, is associated with many physical illnesses. Panax ginseng C. A. Mey (PG) is an important herbal drug which has been used for benefiting Qi for thousand years. Panax ginseng C. A. Mey and its compounds (PGC) possess various pharmacological activities, including anti-fatigue. Here, we conducted a systematic review of both randomized clinical trials (RCTs) and preclinical animal studies to investigate the efficacy and safety of PGC for fatigue. Methods: Electronic searches were performed in 7 databases from the time of each database's inception to August 2019. The methodological quality of RCTs was assessed using 7-item checklist recommended by Cochrane Collaboration or by the CAMARADES 10item quality checklist. All the data were analyzed using Rev-Man 5.3 and Stata SE software. Results: Eight eligible RCTs and 30 animal studies were identified. The risk of bias scores in RCTs ranged from 4/7 to 7/7, and of animal studies varied from 4/10 to 7/10. Metaanalyses showed that PGC was superior to placebo according to their respective fatigue scales, heart rate recovery, and clinical effect (P < 0.05). There were a similar number of adverse effects between PGC and placebo group (P > 0.05). Meta-analyses showed that PGC can significantly decrease level of blood lactate, blood urea nitrogen, creatine kinase, malondialdehyde, and lactic dehydrogenase in serum, level of malondialdehyde in liver and level of gamma-aminobutyric acid, 5-hydroxytryptamine in brain tissue, and increase swimming time, level of glutathione peroxidase, glucose, superoxide dismutase in serum, level of glycogen and activity of superoxide dismutase, glutathione peroxidase, and catalase in skeletal muscle, level of hepatic glycogen in liver and level of dopamine, acetylcholine in brain tissue, compared with control (P < 0.05). Meta-analyses showed no significant difference in animal body weight between PGC and control (P > 0.05). Conclusion: The present findings supported, to a certain degree, that PGC can be recommended for routine use in fatigue. The possible mechanism of PGC resists fatigue, mainly through antioxidant stress, regulating carbohydrate metabolism, delaying the

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“…The MAPP-II SPS has collected detailed information on over 600 UCPPS participants, including their non-urologic symptoms, chronic overlapping pain conditions (COPC), intensity and distribution of their systemic pain, pain characteristics (e.g., neuropathic pain vs. nociceptive pain), psychosocial symptoms (e.g., stress and catastrophizing), and their quantitative sensory testing (QST) and neuroimaging profiles, plus their 3-year longitudinal pain and urinary outcomes, in addition to their HL status. 12 Many of these non-urologic domains have not been examined in details in previous comparative studies. Here we have used the deep phenotyping data from the MAPP-II SPS to address the question of whether UCPPS without HL has more systemic manifestation than those with HL.…”

Section: Introductionmentioning

confidence: 99%

“…The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Phase II Symptom Patterns Study (SPS) is the most comprehensive phenotyping effort of UCPPS to date. The MAPP‐II SPS has collected detailed information on over 600 UCPPS participants, including their non‐urologic symptoms, chronic overlapping pain conditions (COPC), intensity and distribution of their systemic pain, pain characteristics (e.g., neuropathic pain vs. nociceptive pain), psychosocial symptoms (e.g., stress and catastrophizing), and their quantitative sensory testing (QST) and neuroimaging profiles, plus their 3‐year longitudinal pain and urinary outcomes, in addition to their HL status 12 . Many of these non‐urologic domains have not been examined in details in previous comparative studies.…”

Section: Introductionmentioning

confidence: 99%

Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP‐II Research Network Study

Lai

Newcomb

Harte

et al. 2021

Neurourology and Urodynamics

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Objective: To use the phenotyping data from the MAPP-II Symptom Patterns Study (SPS) to compare the systemic features between urologic chronic pelvic pain syndrome (UCPPS) with Hunner lesion (HL) versus those without HL. Methods: We performed chart review on 385 women and 193 men with UCPPS who enrolled in the MAPP-II SPS. 223 had cystoscopy and documentation of HL status. Among them, 12.5% had HL and 87.5% did not. Results: UCPPS participants with HL were older, had increased nocturia, higher Interstitial Cystitis Symptom and Problem Indexes, and were more likely to report "painful urgency" compared with those without HL. On the other hand, UCPPS without HL reported more intense nonurologic pain, greater distribution of pain outside the pelvis, greater numbers of comorbid chronic overlapping pain conditions, higher fibromyalgia-like symptoms, and greater pain centralization, and were more likely to have migraine headache than those with HL. UCPPS without HL also had higher anxiety, perceived stress, and pain catastrophizing than those with HL. There were no differences in sex distribution, UCPPS symptom duration, intensity of urologic pain, distribution of genital pain, pelvic floor tenderness on pelvic examination, quality of life, depression, pain characteristics (nociceptive pain vs. neuropathic pain), mechanical hypersensitivity in the suprapubic area during quantitative sensory testing, and 3-year longitudinal pain outcome and urinary outcome between the two groups. Conclusions: UCPPS with HL displayed more bladder-centric symptom profiles, while UCPPS without HL displayed symptoms suggesting a more Abbreviations: COPC, chronic overlapping pain condition(s); HL, Hunner lesion; MAPP, multidisciplinary approach to the study of chronic pelvic pain; QST, quantitative sensory testing; SPS, symptom pattern study; UCPPS, urologic chronic pelvic pain syndrome.

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The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS)

Cited by 22 publications

References 29 publications

Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study

Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study

Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue

Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP‐II Research Network Study

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