2020
DOI: 10.3389/fphar.2020.01031
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Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue

Abstract: Background: Fatigue, as a complex, multidimensional symptom, is associated with many physical illnesses. Panax ginseng C. A. Mey (PG) is an important herbal drug which has been used for benefiting Qi for thousand years. Panax ginseng C. A. Mey and its compounds (PGC) possess various pharmacological activities, including anti-fatigue. Here, we conducted a systematic review of both randomized clinical trials (RCTs) and preclinical animal studies to investigate the efficacy and safety of PGC for fatigue. Methods:… Show more

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Cited by 17 publications
(14 citation statements)
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“…ΚΕGG analysis demonstrated the enrichment of hub genes in cancer as well as infection pathways, which corroborated the antiinflammatory role of HYJJ. In the formula, combating inflammation was the principal target accomplished by eight herbs, such as ACD, ZR, GF, PGM (Jin et al, 2020), PB (Tian et al, 2020), SCF (Li et al, 2020;Li et al, 2021), PCW as well as CC (Csikos et al, 2020). In addition to inflammation, the recovery of gut motility and orchestration of the gut innervation were also underlined.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ΚΕGG analysis demonstrated the enrichment of hub genes in cancer as well as infection pathways, which corroborated the antiinflammatory role of HYJJ. In the formula, combating inflammation was the principal target accomplished by eight herbs, such as ACD, ZR, GF, PGM (Jin et al, 2020), PB (Tian et al, 2020), SCF (Li et al, 2020;Li et al, 2021), PCW as well as CC (Csikos et al, 2020). In addition to inflammation, the recovery of gut motility and orchestration of the gut innervation were also underlined.…”
Section: Discussionmentioning
confidence: 99%
“…Among these herbs, the combination of ACD, ZR and GF also termed by Si-Ni decoction has shown proven efficacy for septic shock (Chen et al, 2011), sepsis (Brislinger et al, 2018;Zeng et al, 2019) by interfering with apoptosis and inflammatory responses (Aly et al, 2005;Endo et al, 2017;Yang et al, 2017;Endo et al, 2018;Bai et al, 2020). In the context of SI-NI decoction, the anti-inflammatory function has been emphasized by the addition of PGM (Jin et al, 2020), PB (Tian et al, 2020), SCF (Panossian & Wikman, 2008;Li et al, 2020;Li et al, 2021), PCW as well as CC (Csikos et al, 2020). Moreover, focusing on the impaired gastrointestinal functions, AMK is included to improve gastrointestinal motility (Zhu et al, 2018;Yang et al, 2019) and restore immune homeostasis (Xiang et al, 2020), while CR maintains homeostasis of the gut microbiota (Chen et al, 2020) and inhibits inflammation (Ho & Lin, 2008;Herath et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Su efecto ergogénico es atribuido, principalmente, a sus compuestos bioactivos tales como ginsenósidos y ciwujianosides (Williams, 2006). También se ha recomendado este suplemento en casos de fatiga, para mejorar el acondicionamiento aeróbico, la fuerza y la recuperación post-ejercicio (Jin et al, 2020).…”
Section: Ginseng (Panax Ginseng Camey)unclassified
“…Especially, Korean red ginseng (KRG), which is manufactured by repeated steaming and drying of raw ginseng, is known to exert pharmacologic activities, including antifatigue, antioxidative, and immunomodulatory effects [ 15 , 16 ]. To date, studies on the anti-fatigue effects of P. ginseng and KRG have focused on general or peripheral fatigue and have mainly involved measurement of energy metabolite- and oxidative stress-related marker levels in blood and tissues from clinical patients and animal models [ 17 ]. However, regarding central fatigue, evidence of the effects of P. ginseng and KRG is lacking.…”
Section: Introductionmentioning
confidence: 99%