“…Among these herbs, the combination of ACD, ZR and GF also termed by Si-Ni decoction has shown proven efficacy for septic shock (Chen et al, 2011), sepsis (Brislinger et al, 2018;Zeng et al, 2019) by interfering with apoptosis and inflammatory responses (Aly et al, 2005;Endo et al, 2017;Yang et al, 2017;Endo et al, 2018;Bai et al, 2020). In the context of SI-NI decoction, the anti-inflammatory function has been emphasized by the addition of PGM (Jin et al, 2020), PB (Tian et al, 2020), SCF (Panossian & Wikman, 2008;Li et al, 2020;Li et al, 2021), PCW as well as CC (Csikos et al, 2020). Moreover, focusing on the impaired gastrointestinal functions, AMK is included to improve gastrointestinal motility (Zhu et al, 2018;Yang et al, 2019) and restore immune homeostasis (Xiang et al, 2020), while CR maintains homeostasis of the gut microbiota (Chen et al, 2020) and inhibits inflammation (Ho & Lin, 2008;Herath et al, 2016).…”