The mRNA expression profile of the goat prion protein testis-specific (PRNT) gene and its associations with litter size

Bi, Yi; Zhang, Shaoli; Li, Jie; He, Libang; Kang, Yuxin; Chen, Hong; Lan, Xianyong; Pan, Chuanying

doi:10.1016/j.theriogenology.2021.02.013

Cited by 14 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is extremely important to improve the accuracy and predictability of the selection of superior genotypes for quantitative traits in the breeding process. To date, many quantitative trait loci (QTLs) affecting important economic traits in goats have been found [19,35].…”

Section: Discussionmentioning

confidence: 99%

“…They were raised on a Shaanbei white cashmere goat farm in Shaanxi Province. All the goats were kept under standard conditions, including the same diet and feeding and management conditions [1,19]. The feeding programs were as follows: all the kids were continuously kept with their dams until weaning at the age of 3 months.…”

Section: Animal Samples and Data Collectionmentioning

confidence: 99%

See 1 more Smart Citation

Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits

Bai

Yuan

Luo

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

The A-kinase anchoring protein 12 gene (AKAP12) is a scaffold protein, which can target multiple signal transduction effectors, can promote mitosis and cytokinesis and plays an important role in the regulation of growth and development. In our previous study, P1–7 bp (intron 3) and P2–13 bp (3′UTR) indels within the AKAP12 gene significantly influenced AKAP12 gene expression. Therefore, this study aimed to identify the association between these two genetic variations and growth-related traits in Shaanbei white cashmere goats (SBWC) (n = 1405). Herein, we identified two non-linkage insertions/deletions (indels). Notably, we found that the P1–7 bp indel mutation was related to the height at hip cross (HHC; p < 0.05) and the P2–13 bp indel was associated with body weight, body length, chest depth, chest width, hip width, chest circumference and cannon (bone) circumference in SBWC goats (p < 0.05). Overall, the two indels’ mutations of AKAP12 affected growth traits in goats. Compared to the P1–7 bp indel, the P2–13 bp indel is more suitable for the breeding of goat growth traits.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Animal Samples and Data Collectionmentioning

confidence: 99%

Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits

Bai

Yuan

Luo

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is regarded as the most preferable DNA marker in genetic and molecular breeding since its tracking availability, ease of interpretation and suitability for various genotyping techniques ( Kruglyak, 1997 ). Many studies conferred that SNP markers could be used for the breeding of livestock, of which the fundamental goal is to use these mutations as useful markers for the prediction of superior animals concerning the desired production traits ( Xiang et al, 2018 ; Bi et al, 2021 ; Gautason et al, 2021 ). Nowadays, the candidate gene association study (CGAS) ( Moon, 2019 ) has been widely used to identify genetic variants of candidate genes and their potential association with certain genotype traits ( Pryce et al, 2011 ; Locke et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Five SNPs Within the FGF5 Gene Significantly Affect Both Wool Traits and Growth Performance in Fine-Wool Sheep (Ovis aries)

Zhao

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Fibroblast growth factor 5 (FGF5) gene, a member of fibroblast growth factor superfamily, plays significant roles in the regulation of the hair growth cycle during the development of mammalian hair follicles as well as the skeletal muscle development. In this study, DNA sequencing was used to scan the putative SNPs within the full-length of FGF5 gene, and SNPscan high-throughput technique was applied in the individual genotyping of 604 crossbred sheep. 10 SNPs were identified within FGF5 gene while five of them located in intron 1 could be genotyped, namely SNP1 (g. 105914953 G > A), SNP2 (g. 105922232 T > C), SNP3 (g. 105922244 A > G), SNP4 (g. 105922334 A > T) and SNP5 (g. 105922340 G > T). All these SNPs were in accord with the Hardy-Weinberg equilibrium (P > 0.05), and displayed the moderate polymorphism with PIC values ranging from 0.302 to 0.374. Thereafter, the correlation analysis between each SNP locus and economic traits including wool length, greasy wool weight and growth performance of sheep was systematically implemented. In our results, SNP1, SNP3, SNP4 and SNP5 were significantly associated with wool length, greasy wool weight and growth traits of SG sheep (P < 0.05); SNP1, SNP2, SNP3, and SNP4 were significantly correlated with wool length and growth traits of SSG sheep (P < 0.05). Meanwhile, our study revealed a strong linkage disequilibrium (LD) relationship among these SNPs (r2 > 0.33), except for SNP3 and SNP4 sites (r2 = 0.30). Combination genotype analysis showed that combination genotypes were significantly associated with mean fiber diameter of SG (P < 0.05), and body weight trait of SSG (P < 0.01). The above findings suggested that these SNP loci might affect economic traits synergistically and could be regarded as potential molecular markers for improving both wool production and growth performance of fine-wool sheep, which lay a molecular foundation for the breeding of fine dual-purpose sheep thereby accelerating the pace of sheep breeding.

show abstract

“…Variants associated with bovine fertility [10], as well as single-nucleotide polymorphism (SNP) markers that are correlated with variation in beef heifer reproduction and performance of their calves, have been identified [11]. Similarly, the association between SNPs within PRNT genes and fertility has been explored in goats [12]. However, whether the candidate genes selected through GWAS have practical significance remains to be verified.…”

Section: Introductionmentioning

confidence: 99%

Fertility-Associated Polymorphism within Bovine ITGβ5 and Its Significant Correlations with Ovarian and Luteal Traits

Zhao

Jiang

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

There is an urgent need to improve bovine fertility, and molecular marker-assisted selection (MAS) can accelerate this process. Genome-wide association studies suggest that Integrin β5 (ITGβ5) might affect fertility in bovines. As a member of the integrins family, ITGβ5 can bind to the extracellular matrix and mediate various cellular processes. In our study, primers spanning six potential insertion/deletion (indel) polymorphisms within the ITGβ5 gene were designed and 696 ovary samples from different individuals, the vast majority not in oestrum were collected for genetic variation detection. A deletion locus, rs522759246, namely P1-D13-bp, was found to be polymorphic. The allele D frequency was 0.152 and the polymorphism information content (PIC) value was 0.224, indicating a low-degree PIC. This locus did not follow the Hardy–Weinberg equilibrium (p = 1.200E-23). Importantly, associations between P1-D13-bp and ovarian morphological traits were established. Polymorphisms of this locus had significant correlations with ovarian width (p = 0.015). The corpus luteum is also linked to fertility and P1-D13-bp was significantly correlated with corpus luteum diameter (p = 0.005). In conclusion, an indel mutation within the bovine ITGβ5 gene was identified, which was significantly associated with several ovarian and luteal traits.

show abstract

The mRNA expression profile of the goat prion protein testis-specific (PRNT) gene and its associations with litter size

Cited by 14 publications

References 33 publications

Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits

Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits

Five SNPs Within the FGF5 Gene Significantly Affect Both Wool Traits and Growth Performance in Fine-Wool Sheep (Ovis aries)

Fertility-Associated Polymorphism within Bovine ITGβ5 and Its Significant Correlations with Ovarian and Luteal Traits

Contact Info

Product

Resources

About