“…More recently, MRI has been used to measure changes in wall thickness and chamber volume (Costandi, et al, 2007) during heart contractions. Similar studies have monitored changes in cartilage thickness (Eckstein, et al, 2005), and joint kinematics (Freeman and Pinskerova, 2005) during joint articulation. In vitro studies with video microscopy have revealed marked spatial variation in the deformation and strain in articular cartilage (Schinagl, et al, 1997, Schinagl, et al, 1996, Wang, et al, 2002, and the deformation of single cells (Gilchrist, et al, 2007).…”