The Mouse-Adapted Lansing Strain Op Poliomyelitis Virus

Turner, Thomas B.; Young, Lawrence E.; Maxwell, Elizabeth Starbuck

doi:10.1093/oxfordjournals.aje.a119029

Cited by 4 publications

(1 citation statement)

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“…They were chosen because it was predicted that neutralizing antibody of Lansing type would be present, since this antibody is distributed among the population in a manner that increases with age, until adolescence or adulthood, when almost all individuals have it (11)(12)(13). As expected, all had a high level of Lansing-type neutralizing antibody; there were fewer CF positives, and at a lower level, than were found among those obtained from poliomyelitis convalescents.…”

Section: Antigensmentioning

confidence: 95%

A Specific Complement-Fixation Test for Infection With Poliomyelitis Virus

Casals

Olitsky

Anslow

1951

Journal of Experimental Medicine

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A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.

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Section: Antigensmentioning

confidence: 95%