Mechanism of immunity in poliomyelitis and its bearing on differentiation of types

Immunological Reactions in Viral Diseases

“…In one type, monkeys were sub jected to repeated parenteral inoculations with a specific strain of living virus, challenged by intracerebral route with the same strain and, if symp tomless, were given one more parenteral injection of the homologous virus. These animals were then divided in groups and challenged with large intra cerebral doses of unknown strains (104,105,106). In the second type ottest, rhesus monkeys convalescing from an experimentally induced attack with a known strain of virus were challenged by the intracerebral route with un known strains (107,108).…”