The motor response to intestinal resection: Motor activity in the canine small intestine following distal resection

Quigley, Eamonn Martin; Thompson, Jon S.

doi:10.1016/0016-5085(93)90897-l

Cited by 60 publications

(20 citation statements)

References 26 publications

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“…The conventional doctrine is that motor patterns influence the size, location and diversity of the microbiota; thus the clinical association between a variety of motor disorders and SIBO. That the microbiota can influence motor patterns has been vividly illustrated, not only by the aforementioned studies in the germ-free animal, but also in experimental models of the short bowel syndrome where resection of extensive portions of normal, more distal small intestine result in profound motor disruption in the more proximal remnant 22. These dramatic motor changes occur in the context of a dramatic increase in the bacterial population, as well as the concentration of a bacterial product, short chain fatty acids, in the remnant 23-25…”

Section: Motility-microbiota Interactions: the Basicsmentioning

confidence: 99%

Microflora Modulation of Motility

Quigley¹

2011

J Neurogastroenterol Motil

100

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That gastrointestinal motility can influence the gut microbiota has been known for decades and the clinical consequences of impaired motility, in terms of the bacterial population of the small intestine, amply illustrated by the syndrome of small intestinal bacterial overgrowth which so commonly accompanies diffuse intestinal motility disorders. As the importance of the microbiota to homeostasis in health and to a variety of disease states is increasingly appreciated and as the full diversity and biology of this "hidden organ" have been revealed by molecular methodologies, the true nature of the interaction between the microbiota and motility is being re-examined and the complexity of this relationship exposed. In health, as well as in disease states, this is a truly bi-directional relationship: not only can gut motor patterns influence the microbiota but changes in the microbiota can exert profound influences on gut sensori-motor function.

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Section: Motility-microbiota Interactions: the Basicsmentioning

confidence: 99%

Microflora Modulation of Motility

Quigley¹

2011

J Neurogastroenterol Motil

100

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show abstract

“…Methods-Seven patients with a short bowel syndrome after total ileal and partial jejunal resection (residual jejunal segments between 60 and 100 cm) and six patients with limited distal ileal resection (resected segment between 30 and 70 cm) underwent ambulatory 24 hour jejunal manometry 15 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) months after the operation. Normal values were obtained from 50 healthy subjects.…”

mentioning

confidence: 99%

Effect of intestinal resection on human small bowel motility.

Schmidt¹,

Pfeiffer²,

Hackelsberger³

et al. 1996

Gut

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“…To mimic this condition, the transit times and the length of duodenum and jejunum compartments in ACAT model were set to zero. Data suggest that the transit time of small intestine is increased [4,24,26], Quigley et al found that the small intestinal transit time is increased by 35% following 50% resections of dogs small instinet and by 29% following 75% of the resections [27]. Therefore, the transit time of the ileum was increased by 32% especially that the RYGB resections, to some extent, is variable.…”

Section: Post Rygb Groupmentioning

confidence: 93%