Effect of intestinal resection on human small bowel motility.

Intrinsic Myenteric Denervation: A New Model to Increase the Intestinal Absorptive Surface in Short-Bowel Syndrome

“…It should be pointed out that SBS leads to abnormalities in intestinal motility that may contribute to the malabsorption observed in the patients [12,13]. By reducing intestinal motility, myenteric denervation could avoid some of these jeopardizing responses and, therefore, ameliorate the symptoms of SBS.…”

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

“…Removal of bowel tissue results in a shortening of the intestine and reduced transit distance through the GI tract, which potentially affects the way conventional oral formulations are processed. Beyond this, resection profoundly changes the physiology of the intestinal tract by altering pH, nutrient absorption, digestion and transit (57)(58)(59). In particular, resection of the terminal ileum alters water absorption and dilutes residual bile acids in the colon, therefore reducing net colonic fatty acid concentrations (60,61).…”

Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice

“…Animal models used to study adaptation demonstrate early increases in proliferation of crypt epithelium leading to enhanced crypt depth, villus height, microvillus surface area, and functional absorptive capacity per unit length of intestine to compensate for the loss of mucosal surface area. Strong evidence supports a role of luminal nutrients (9,12,26), gastrointestinal secretions (1,45), mesenchymal (38), neuronal (39,40), and humoral factors (41,45,46) in regulating the adaptive response (27). A majority of studies in animal models have focused on early adaptive growth responses after bowel resection.…”