The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy

Rajabi, Sadegh; Maresca, Marc; Yumashev, Alexei Valerievich; Choopani, Rasool; Hajimehdipoor, Homa

doi:10.3390/biom11040534

Cited by 62 publications

(28 citation statements)

References 144 publications

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“…Bcl-2 is a member of a large family of cell survival regulating proteins consisting of both pro-and anti-apoptotic regulators. The bax/bcl-2 regulation is predominant mechanism of apoptosis evasion used by cancers [45]. We therefore assessed the activity level of bax, bcl-2, and caspase-3 genes.…”

Section: Discussionmentioning

confidence: 99%

Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release

Alotaibi

Bepari

Assiri

et al. 2021

CIMB

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Background and Objectives: Saussurea lappa (S. lappa) is an important species of the Asteraceae family with several purposes in traditional medicine. This study intended to explore the cytotoxic effect of S. lappa on HepG2 cancer cell proliferation. Materials and Methods: The effects of an S. lappa n-butanol extract on the induction of apoptosis were investigated by flow cytometry and mitochondrial cytochrome C-releasing apoptosis assay. Additionally, real-time PCR was employed to confirm apoptosis initiation. Further, qualitative estimation of the active constituent of S. lappa was done by gas chromatography–mass spectroscopy (GC–MS). Results: The cell viability study revealed that the n-butanol extract of S. lappa demonstrated potent cytotoxicity against HepG2 cancer cells, with an IC50 value of 56.76 μg/mL. Cell morphology with dual staining of acridine orange (AO)-ethidium bromide (EB) showed an increase in orange/red nuclei due to cell death by S. lappa n-butanol extract compared to control cells. Apoptosis, as the mode of cell death, was also confirmed by the higher release of cytochrome C from mitochondria, the increased expression of caspase-3 and bax, along with down regulation of Bcl-2. Conclusion: These findings conclude that S. lappa is a cause of hepatic cancer cell death through apoptosis and a potential natural source suggesting furthermore investigation of its active compounds that are responsible for these observed activities.

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Section: Discussionmentioning

confidence: 99%

Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release

Alotaibi

Bepari

Assiri

et al. 2021

CIMB

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“…Hypericum perforatum 17 . Calophylum inophylum 18 , Gamboge hanburyi 19. and Artocarpus optusus 20 . Xanthones have an antiinflammatory effect by inhibiting COX-2 and prostaglandin synthesis at glioma cell in rats 21 .…”

Section: Fig 1: Structure Of Xanthonementioning

confidence: 98%

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2021

IJPSR

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A series of 3,6-bis (3 / -substituted propoxy) and 3,6-bis (5 /substituted pentyloxy) xanthone derivatives was synthesized by the condensation of 3,6-bis (3 / -bromopropoxy) and 3,6-bis (5 / -bromopentyloxy) xanthones with primary or secondary amines. These compounds were characterized by FT-IR, 1 H NMR, and Mass spectral data. The anti-inflammatory study of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method on Albino rats of Wistar strains. Thirty minutes after injection of 1% carrageenan solution into the sub plantar surface of the left hind paw, synthesized drugs were orally administered at a dose of 100 &200 mg/kg body weight. The compounds S3, S17, and S20 at a dose of 200 mg/kg body weight showed 63.32%,62.75%, and 60.71% paw edema reduction respectively after 6 hours as compared to standard diclofenac (10mg/kg) body weight which showed 68.27% reduction of paw edema after 6 hours. The molecular docking studies were also carried out in the active site of COX-2 enzymes (PDB ID: 1CX2) using Discovery studio version 2.5. The in-silico ligand binding interactions of compounds S3 , S6 , S14 , S17, and S20 suggested approx.> 30% higher binding energy values than the standard Diclofenac (Binding energy -155.46 Kcal/mol). A significant correlation was observed between the in-silico and the in-vivo studies of the synthesized compounds. With the help of anti-inflammatory and docking, the synthesized compounds S3 , S17, and S20 could be considered as possible hits as anti-inflammatory agents. INTRODUCTION:Inflammation is essentially a protective response and the body"s way of dealing with infections which involves a complex series of enzyme activation, mediator release, fluid, extra vacations, cell migration, tissue breakdown, and repair 1 .

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“…In BC cells, multiple factors, including growth factor, DNA damage, reactive oxygen species (ROS), and UV radiation, can promote uncontrolled cell growth through mitochondrial, FasL/Fas-, PI3K/AKT-, ROS-, nuclear factor κB (NF-κB)-, and MAPK-mediated pathways, to break the balance of proapoptotic and antiapoptotic effects. Therefore, targeting apoptotic pathways is an efficient strategy for identifying candidate drugs derived from natural products to treat BC (Rajabi et al, 2021).…”

Section: Apoptosis and Bcmentioning

confidence: 99%

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

et al. 2022

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Breast cancer is one of the top-ranked malignant carcinomas associated with morbidity and mortality in women worldwide. Chemotherapy is one of the main approaches to breast cancer treatment. Breast cancer initially responds to traditional first- and second-line drugs (aromatase inhibitor, tamoxifen, and carboplatin), but eventually acquires resistance, and certain patients relapse within 5 years. Chemotherapeutic drugs also have obvious toxic effects. In recent years, natural products have been widely used in breast cancer research because of their low side effects, low toxicity, and good efficacy based on their multitarget therapy. Apoptosis, a programmed cell death, occurs as a normal and controlled process that promotes cell growth and death. Inducing apoptosis is an important strategy to control excessive breast cancer cell proliferation. Accumulating evidence has revealed that natural products become increasingly important in breast cancer treatment by suppressing cell apoptosis. In this study, we reviewed current studies on natural product–induced breast cancer cell apoptosis and summarized the proapoptosis mechanisms including mitochondrial, FasL/Fas, PI3K/AKT, reactive oxygen species, and mitogen-activated protein kinase–mediated pathway. We hope that our review can provide direction in the search for candidate drugs derived from natural products to treat breast cancer by promoting cell apoptosis.

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The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy

Cited by 62 publications

References 144 publications

Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release

Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release

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Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

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