The morphogenesis of the thyroid follicles of the chick

Bradway, Winnefred E.

doi:10.1002/ar.1090420206

Cited by 41 publications

(3 citation statements)

References 12 publications

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“…The rabbit thyroid grafts slowed the development of the host thyroid as shown by the lack of follicle formation or of colloid-containing follicles. In some cases the thyroid cells formed ' cords ' (Norris, 1916) or were arranged typically for the prefollicular stage of thyroid development in the 11-day-old chick (Bradway, 1929). This result was probably due to the great amount of thyroxine supplied to the embryo by the thyroid heterografts, in contrast to Willier's (1924) observations on the effects of embryonic thyroid homografts.…”

Section: Discussionmentioning

confidence: 91%

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The Development of Thyroid-Stimulating Hormone-Releasing Factor Activity in the Neonatal Rabbit

Slebodzinski¹,

Mach²,

Malinowska³

1971

Journal of Endocrinology

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Nine-day chick embryos received grafts of hypothalamus, adenohypophysis, thyroid, and fat (controls) from 0-, 7-, 14-and 21-day-old rabbits to the chorio-allantois. In addition, aqueous rabbit adenohypophysial and hypothalamic extracts were given to 1-day-old chicks. Animals injected with thyrotrophin and saline served as controls. On the 5th day of incubation of treated embryos, or 24 h after the administration of the extracts, the chicks were killed and their thyroids studied histologically.The hypothalamic grafts or extracts activated the chick thyroid gland and a similar trend was found in adenohypophysial or thyroid-stimulating hormone-treated chicks. The degree of activation of the embryo chick thyroid gland was related to the age of the donor rabbit. In general, thyroidstimulating hormone-releasing factor activity in hypothalamic heterografts or extracts appeared first in 14-day-old rabbits and was correlated with increasing thyrotrophic potency of the rabbit adenohypophysis. a comparison was made between the newborn pig and rabbit, as representatives of poikilothermic and homeothermic animals at birth, with respect to the hypothalamopituitary-thyroid system (Slebodzinski & Srebro, 1968). It was shown that in the

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Section: Discussionmentioning

confidence: 91%

“…Primary thyroid follicles with very lightly staining colloid are seen for the first time in the 11-day-old chick (Bradway, 1929) and respond to thyrotrophic hormone on day 12. Within 24 h after TSH injection the gland appeared active with a high follicular epithelium and a lack of stored colloid (Woodside, 1937).…”

Section: Discussionmentioning

confidence: 99%

The Development of Thyroid-Stimulating Hormone-Releasing Factor Activity in the Neonatal Rabbit

Slebodzinski¹,

Mach²,

Malinowska³

1971

Journal of Endocrinology

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“…As a result, the epithelial mass becomes subdivided into cords which will further subdivide to form follicles (6,22). Before the mesenchymal cells invade, channels which contain fibrillar material appear between the epithelial cells toward the center of the primordium (manuscript in preparation, for preliminary report see reference 14).…”

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confidence: 99%

Interference with thyroid histogenesis by inhibitors of collagen synthesis.

Hilfer¹,

Pakstis²

1977

The Journal of Cell Biology

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Histogenesis of thyroid follicles in the chick embryo begins with a penetration by cells of the mesenchymal capsule into a solid epithelial primordium. Before penetration occurs, slits containing fibrillar material form between the epithelial cells. The fibrillar material is an epithelial cell product as shown by its formation within channels that form in cultures of isolated epithelial primordia. The drugs Lazetidine-2-carboxylic acid (LACA) and a, c~'-dipyridyl, which interfere with collagen synthesis, prevent the formation of fibrils in cultured epithelial primordia and in cultures of whole thyroids. Furthermore, mesenchymal cells do not invade when whole thyroid primordia are cultured in the presence of either drug. The effects of a, a'-dipyridyl are reversed by washing out the drug; the effects of LACA are reversed by incubation with equimolar or greater amounts of L-proline added to the medium along with the drug. The results are interpreted to mean that the fibrillar material is collagen of epithelial origin, that the collagen in some way plays a role in mesenchymal penetration of the epithelial primordium, and that the epithelium is responsible for the pattern of lobulation within the developing gland.

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Ultrastructure of the thyroid in dwarf mice

André

Denef²,

Haumont³

1976

Am. J. Anat.

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The thyroid gland of Snell's dwarf mice consists of small follicles with flattened epithelium, partly differentiated cords and undifferentiated masses. Many adipocytes are found. The ultimobranchial cysts are well developed. Parafollicular cells are normal. In the partly organized cords, microfollicular cells are some small follicles limited by two or three cells are seen. The presence of these structures led us to think that they represent the first stages of normal folliculogenesis, described as the fusion of two adjacent unicellular microfollicles. Their further growth is the result of the coalescing of small adjacent follicles or of cellular multiplication. The presence of undifferentiated masses and partly differentiated cords, in dwarf mice, seems due to a developmental arrest rather than to aberrant development. This disorder of organogenesis is ascribed mainly to a lack of pituitary growth hormone.

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The morphogenesis of the thyroid follicles of the chick

Cited by 41 publications

References 12 publications

The Development of Thyroid-Stimulating Hormone-Releasing Factor Activity in the Neonatal Rabbit

The Development of Thyroid-Stimulating Hormone-Releasing Factor Activity in the Neonatal Rabbit

Interference with thyroid histogenesis by inhibitors of collagen synthesis.

Ultrastructure of the thyroid in dwarf mice

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