The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera)

Mathur, Deepali; Goyal, Kritika; Koul, Veena; Anand, Akshay

doi:10.3389/fphar.2016.00044

Cited by 69 publications

(38 citation statements)

References 79 publications

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“…The medicinal herbs analyzed here are reported to alter host signaling via the gut-immune-brain axis [ 43 – 49 ]. A growing number of studies have linked the gut microbiota as a factor in the gut-brain axis [ 50 – 55 ].…”

Section: Discussionmentioning

confidence: 99%

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics

et al. 2019

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The prebiotic potential of nervine herbal medicines has been scarcely studied. We therefore used anaerobic human fecal cultivation to investigate whether medicinal herbs commonly used as treatment in neurological health and disease in Ayurveda and other traditional systems of medicine modulate gut microbiota. Profiling of fecal cultures supplemented with either Kapikacchu, Gotu Kola, Bacopa/Brahmi, Shankhapushpi, Boswellia/Frankincense, Jatamansi, Bhringaraj, Guduchi, Ashwagandha or Shatavari by 16S rRNA sequencing revealed profound changes in diverse taxa. Principal coordinate analysis highlights that each herb drives the formation of unique microbial communities predicted to display unique metabolic potential. The relative abundance of approximately one-third of the 243 enumerated species was altered by all herbs. Additional species were impacted in an herb-specific manner. In this study, we combine genome reconstruction of sugar utilization and short chain fatty acid (SCFA) pathways encoded in the genomes of 216 profiled taxa with monosaccharide composition analysis of each medicinal herb by quantitative mass spectrometry to enhance the interpretation of resulting microbial communities and discern potential drivers of microbiota restructuring. Collectively, our results indicate that gut microbiota engage in both protein and glycan catabolism, providing amino acid and sugar substrates that are consumed by fermentative species. We identified taxa that are efficient amino acid fermenters and those capable of both amino acid and sugar fermentation. Herb-induced microbial communities are predicted to alter the relative abundance of taxa encoding SCFA (butyrate and propionate) pathways. Co-occurrence network analyses identified a large number of taxa pairs in medicinal herb cultures. Some of these pairs displayed related culture growth relationships in replicate cultures highlighting potential functional interactions among medicinal herb-induced taxa.

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Section: Discussionmentioning

confidence: 99%

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics

et al. 2019

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“…In a clinical trial, brahmi improved cognition in patients with senile dementia of the Alzheimer-type. Alongside the improved cognition, various biochemical markers showed reduced inflammation (homocysteine, C-reactive protein, and tumor necrosis factor alpha) and oxidative stress (glutathione peroxidase, glutathione, thiobarbituric acid reactive substances, and superoxide dismutase) [122].…”

Section: Curcumin and Other Ayurvedic Herbsmentioning

confidence: 95%

A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways

Vegh

Stokes

et al. 2019

JAD

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Neurons consume the highest amount of oxygen, depend on oxidative metabolism for energy, and survive for the lifetime of an individual. Therefore, neurons are vulnerable to death caused by oxidative-stress, accumulation of damaged and dysfunctional proteins and organelles. There is an exponential increase in the number of patients diagnosed with neurodegenerative diseases such as Alzheimer's (AD) as the number of elderly increases exponentially. Development of AD pathology is a complex phenomenon characterized by neuronal death, accumulation of extracellular amyloid-␤ plaques and neurofibrillary tangles, and most importantly loss of memory and cognition. These pathologies are most likely caused by mechanisms including oxidative stress, mitochondrial dysfunction/stress, accumulation of misfolded proteins, and defective organelles due to impaired proteasome and autophagy mechanisms. Currently, there are no effective treatments to halt the progression of this disease. In order to treat this complex disease with multiple biochemical pathways involved, a complex treatment regimen targeting different mechanisms should be investigated. Furthermore, as AD is a progressive disease-causing morbidity over many years, any chemo-modulator for treatment must be used over long period of time. Therefore, treatments must be safe and non-interfering with other processes. Ideally, a treatment like medicinal food or a supplement that can be taken regularly without any side effect capable of reducing oxidative stress, stabilizing mitochondria, activating autophagy or proteasome, and increasing energy levels of neurons would be the best solution. This review summarizes progress in research on different mechanisms of AD development and some of the potential therapeutic development strategies targeting the aforementioned pathologies.

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“…Bacoside A is the most potent constituent of Bacopa, which is composed of bacoside A3, bacopasaponin C, bacopaside II, and bacopaside X (Deepak M et al, 2013). BM is used in treatment of alzheimers, schizophrenia, and has anti-parkinsonian, antistroke, anticonvulsant potentials (Mathur et al, 2016). The anti-parkinson effect of baccopa is evaluated by Siddique et al in Drosophila fly their findings propose that, baccopa improves neuronal survival by obstructing oxidation of cells, and improving functional capacity i.e.…”

Section: E Bacopa Monnieramentioning

confidence: 99%

The Counteracting Performance of Phytoconstituents Against Neurodegeneration Involved in Parkinson's Disease

Doke¹,

Pansare²,

Sainani³

et al. 2021

JSR

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Parkinson's disease (PD) is age associated neurodegenerative disorder of the central nervous system. The PD is marked by selective degeneration of dopamine neuron in the specific part of brain called substaintia nigra which leads to several motor and non-motor symptoms. The cause of diseases rests uncertain, however the factors like oxidative stress, aggregation of alpha-synuclein protein, mitochondrial dysfunction, neuroinflammation and many others contribute in development of Parkinson's disease. The current available pharmaco-therapeutics, focused on replenishing the striatal dopamine level but none of them able to halt disease progression. The existing treatment is hindered by the definite boundaries such as it fails to cure disease, provide only symptomatic relief, safety issues and cost of treatment is also more. As the existing treatments are hindered by therapeutic restrictions and with certain adversarial effects; thus, there is a requirement to improve fresh in addition other operative medications with less adversarial effects. The purpose of present manuscript is to explore the capability of phytoconstituents with neuroprotective assets counter to neurodegeneration concerned in PD and encourage expansion of future novel management approaches supported by natural sources.

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The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera)

Cited by 69 publications

References 79 publications

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics

A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways

The Counteracting Performance of Phytoconstituents Against Neurodegeneration Involved in Parkinson's Disease

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