The Counteracting Performance of Phytoconstituents Against Neurodegeneration Involved in Parkinson's Disease

Abstract

Parkinson's disease (PD) is age associated neurodegenerative disorder of the central nervous system. The PD is marked by selective degeneration of dopamine neuron in the specific part of brain called substaintia nigra which leads to several motor and non-motor symptoms. The cause of diseases rests uncertain, however the factors like oxidative stress, aggregation of alpha-synuclein protein, mitochondrial dysfunction, neuroinflammation and many others contribute in development of Parkinson's disease. The current available pharmaco-therapeutics, focused on replenishing the striatal dopamine level but none of them able to halt disease progression. The existing treatment is hindered by the definite boundaries such as it fails to cure disease, provide only symptomatic relief, safety issues and cost of treatment is also more. As the existing treatments are hindered by therapeutic restrictions and with certain adversarial effects; thus, there is a requirement to improve fresh in addition other operative medications with less adversarial effects. The purpose of present manuscript is to explore the capability of phytoconstituents with neuroprotective assets counter to neurodegeneration concerned in PD and encourage expansion of future novel management approaches supported by natural sources.

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