The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films

Fadda, Hala M.; Hernández, María Cristina; Margetson, Daniel N.; McAllister, S. Mark; Basit, Abdul W.; Brocchini, Stephen; Suárez, N.

doi:10.1002/jps.21292

Cited by 18 publications

(6 citation statements)

References 37 publications

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“…TEC, the least effective plasticizer, only differs structurally from TBC in the number of carbons in its ester chain; TEC containing two carbons while TBC having four (see Table II). Both plasticizers have three ester functionalities, potentially acting as a hydrogen bond acceptor sites and a tertiary hydroxyl group, which has both hydrogen bond donating and accepting character 17. Interactions may occur between the hydroxyl groups of TEC/TBC and the hydrogen bond acceptor ester groups of PDLLA.…”

Section: Resultsmentioning

confidence: 99%

The effect of citrate ester plasticizers on the thermal and mechanical properties of poly(DL‐lactide)

Harte

Birkinshaw

Jones

et al. 2012

J of Applied Polymer Sci

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Citrate esters triethyl citrate, tributyl citrate, and acetyl tributyl citrate were used as plasticizers for amorphous poly(D,Llactide) (PDLLA). The resultant compositions were analyzed by means of differential scanning calorimetry (DSC), dynamic mechanical thermal analysis, and tensile testing to investigate the properties of the blends. Glass transition temperatures (T g s) obtained by DSC were also compared to theoretically calculated T g s. Increasing plasticizer content decreased the resultant T g of the blend with plasticizer efficiency enhanced as the molecular weight of the citrate ester increased. However, in blends with high plasticizer content, a lack of miscibility also occurred with increased molecular weight. Theoretical results were comparable with those obtained experimentally at compositions, which were miscible. Increasing plasticizer content increased the ductility and decreased the strength of the polymer. The addition of 10 wt % plasticizer to PDLLA decreased tensile strength by over 50% with the deterioration larger at higher concentrations of plasticizer.

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Section: Resultsmentioning

confidence: 99%

The effect of citrate ester plasticizers on the thermal and mechanical properties of poly(DL‐lactide)

Harte

Birkinshaw

Jones

et al. 2012

J of Applied Polymer Sci

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“…The inclusion of other formulation additives could also influence drug release. For example, the type and amount of plasticizers used in the coating formulation affect the mechanical properties of the coating during dissolution and the drug release rate (H. M. Fadda et al, 2008). It is likely that drug release from the final coated product is determined by the interplay of the different factors.…”

Section: Discussionmentioning

confidence: 99%

In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer

Liu

Shokrollahi

2015

International Journal of Pharmaceutics

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Proton-pump inhibitor (PPI) products based on enteric coated multiparticulates are design to meet the needs of patients who cannot swallow tablets such as children and older adults. Enteric coated PPI preparations exhibit delays in in vivo absorption and onset of antisecretory effects, which is not reflected by the rapid in vitro dissolution in compendial pH 6.8 phosphate buffer commonly used for assessment of these products. A more representative and physiological medium, pH 6.8 mHanks bicarbonate buffer, was used in this study to evaluate the in vitro dissolution of enteric coated multiparticulate-based PPI products. Commercially available omeprazole, lansoprazole and esomeprazole products were subject to dissolution tests using USP-II apparatus in pH 4.5 phosphate buffer saline for 45 min (acid stage) followed by pH 6.8 phosphate buffer or pH 6.8 mHanks bicarbonate buffer. In pH 6.8 phosphate buffer, all nine tested products displayed rapid and comparable dissolution profiles meeting the pharmacopeia requirements for delayed release preparations. In pH 6.8 mHanks buffer, drug release was delayed and failed the pharmacopeia requirements from most enteric coated preparations. Despite that the same enteric polymer, methacrylic acid-ethyl acrylate copolymer (1:1), was applied to all commercial multiparticulate-based products, marked differences were observed between dissolution profiles of these preparations. The use of pH 6.8 physiological bicarbonate (mHanks) buffer can serve as a useful tool to provide realistic and discriminative in vitro release assessment of enteric coated PPI preparations and to assist rational formulation development of these products.

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“…The pH has been measured to be 1-2.5 in the stomach increasing through 6.6±0.5 in the proximal small intestine to a maximum of 7.5±0.4 in the distal small intestine (2). Eudragit S (a polymethacrylic acid methyl methacrylate ester copolymer), with a dissolution threshold of pH 7, is commonly applied as a coating on solid dosage forms to target the colon (3). It was first used by Dew et al (4) which led to the development of Asacol ® (containing 400 mg of mesalazine for the treatment of ulcerative colitis) and other similar products worldwide.…”

Section: Introductionmentioning

confidence: 99%

Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

et al. 2008

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The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films

Cited by 18 publications

References 37 publications

The effect of citrate ester plasticizers on the thermal and mechanical properties of poly(DL‐lactide)

The effect of citrate ester plasticizers on the thermal and mechanical properties of poly(DL‐lactide)

In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer

Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

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