The molecular forms of Anopheles gambiae: A phenotypic perspective

Lehmann, Tovi; Diabaté, Abdoulaye

doi:10.1016/j.meegid.2008.06.003

Cited by 147 publications

(200 citation statements)

References 96 publications

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“…triannulatus s.l. populations from NW and SE Colombia are undergoing speciation, as has been demonstrated for the Anopheles gambiae Complex molecular forms M and S. 66 In addition, the values of intra-population diversity detected (h: 0.972-0.976), indicated that An. triannulatus s.l.…”

Section: Discussionmentioning

confidence: 77%

Genetic Diversity of Anopheles triannulatus s.l. (Diptera: Culicidae) from Northwestern and Southeastern Colombia

Rosero-García¹,

Jaramillo²,

Gutiérrez³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Anopheles triannulatus s.l. is a species complex, however in Colombia its taxonomic status is unclear. This study was conducted to understand the level of genetic differentiation or population structure of specimens of An. triannulatus s.l. from northwestern and southeastern Colombia. Cytochrome oxidase subunit I (COI) and internal transcribed spacer (ITS2) sequence analyses suggested high genetic differentiation between the NW and SE populations. A TCS network and Bayesian inference analysis based on 814 bp of COI showed two main groups: group I included samples from the NW and group II samples from the SE. Two main ITS2-polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) patterns were found. Pattern I is present in both the NW and SE, and pattern II is found in the SE specimens. To further elucidate the taxonomic status of An. triannulatus s.l. in Colombia and how these COI lineages are related to the Triannulatus Complex species, the evaluation of immature stages, male genitalia, and additional mitochondrial and nuclear markers will be needed.

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Section: Discussionmentioning

confidence: 77%

Genetic Diversity of Anopheles triannulatus s.l. (Diptera: Culicidae) from Northwestern and Southeastern Colombia

Rosero-García¹,

Jaramillo²,

Gutiérrez³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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“…gambiae s.s . prefers wetter areas, with small and ephemeral water bodies (Lehmann, Diabate, & Diabaté, 2008); species preferences seem different in forests of Central Africa (Kamdem et al., 2012). Dabiré et al.…”

Section: Discussionmentioning

confidence: 99%

Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae

Assogba

Alout

Koffi

et al. 2018

Evolutionary Applications

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While gene copy‐number variations play major roles in long‐term evolution, their early dynamics remains largely unknown. However, examples of their role in short‐term adaptation are accumulating: identical repetitions of a locus (homogeneous duplications) can provide a quantitative advantage, while the association of differing alleles (heterogeneous duplications) allows carrying two functions simultaneously. Such duplications often result from rearrangements of sometimes relatively large chromosome fragments, and even when adaptive, they can be associated with deleterious side effects that should, however, be reduced by subsequent evolution. Here, we took advantage of the unique model provided by the malaria mosquito Anopheles gambiae s.l. to investigate the early evolution of several duplications, heterogeneous and homogeneous, segregating in natural populations from West Africa. These duplications encompass ~200 kb and 11 genes, including the adaptive insecticide resistance ace‐1 locus. Through the survey of several populations from three countries over 3–4 years, we showed that an internal deletion of all coamplified genes except ace‐1 is currently spreading in West Africa and introgressing from An. gambiae s.s. to An. coluzzii. Both observations provide evidences of its selection, most likely due to reducing the gene‐dosage disturbances caused by the excessive copies of the nonadaptive genes. Our study thus provides a unique example of the early adaptive trajectory of duplications and underlines the role of the environmental conditions (insecticide treatment practices and species ecology). It also emphasizes the striking diversity of adaptive responses in these mosquitoes and reveals a worrisome process of resistance/cost trade‐off evolution that could impact the control of malaria vectors in Africa.

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“…also illustrates multiple axes of differentiation (Sobel et al 2010), at least partly due to a change in pollinator phenology. Even apparently very young M and S morphs of the malarial mosquito, Anopheles gambiae, whose genomes illustrate so-called ''islands of speciation'' (White et al 2010;Turner and Hahn 2010), have diverged in many aspects of the phenotype, such as larval habitat, adult body size, and mate recognition (Lehmann and Diabate 2008). In theory, any of these diverging phenotypes might play an effectual role in curtailing gene flow between diverging forms.…”

Section: Axes Of Differentiationmentioning

confidence: 99%

Genes versus phenotypes in the study of speciation

Shaw

Mullen

2011

Genetica

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Despite persistent debate on the nature of species, the widespread adoption of Mayr's biological species concept has led to a heavy emphasis on the importance of reproductive isolation to the speciation process. Equating the origin of species with the evolution of reproductive isolation has become common practice in the study of speciation, coincident with an increasing focus on elucidating the specific genetic changes (i.e.-speciation genes) underlying intrinsic reproductive barriers between species. In contrast, some have recognized that reproductive isolation is usually a signature effect rather than a primary cause of speciation. Here we describe a research paradigm that shifts emphasis from effects to causes in order to resolve this apparent contradiction and galvanize the study of speciation. We identify major elements necessary for a balanced and comprehensive investigation of the origin of species and place the study of so-called "speciation genes" into its appropriate context. We emphasize the importance of characterizing diverging phenotypes, identifying relevant evolutionary forces acting on those phenotypes and their role in the causal origins of reduced gene flow between incipient species, and the nature of the genetic and phenotypic boundaries that results from such processes. This approach has the potential to unify the field of speciation research, by allowing us to make better "historical" predictions about the fate of diverging populations regardless of taxon.

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The molecular forms of Anopheles gambiae: A phenotypic perspective

Cited by 147 publications

References 96 publications

Genetic Diversity of Anopheles triannulatus s.l. (Diptera: Culicidae) from Northwestern and Southeastern Colombia

Genetic Diversity of Anopheles triannulatus s.l. (Diptera: Culicidae) from Northwestern and Southeastern Colombia

Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae

Genes versus phenotypes in the study of speciation

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