The molecular biology and ocular distribution of prostanoid receptors

Woodward, DF; Regan, John W.; Lake, Staffan; Ocklind, Anette

doi:10.1016/s0039-6257(97)80003-3

Cited by 51 publications

(18 citation statements)

References 40 publications

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“…2011). This notion is supported by the finding of prostaglandin DP, EP, FP and thromboxane receptors (TP) in uveal tissue, suggesting a physiological role of ligands to these receptors that may involve the regulation of vascular tone (Matsuo & Cynader 1992; Woodward et al. 1997; Biswas et al.…”

Section: Introductionmentioning

confidence: 82%

Dual effect of prostaglandins on isolated intraocular porcine ciliary arteries

Kringelholt

Simonsen

Bek

2012

Acta Ophthalmologica

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ABSTRACT.Purpose: Prostaglandin analogues are used to reduce the intraocular pressure (IOP) in glaucoma, but also affect the tone of the arteries supplying the ciliary body. Previously, the effect of prostaglandins has been studied on the extraocular ciliary arteries, whereas the effect on intraocular ciliary arteries has not been studied in detail. Methods: Intraocular long posterior porcine ciliary arteries were isolated and mounted in a myograph system for isometric tension recording, and the effects of PGF 2a , the prostaglandin analogue latanoprost, PGD 2 , PGE 2 , PGI 2 and the thromboxane analogue U46619 were studied in the presence and absence of selective receptor antagonists. Results: The prostaglandins PGD 2 and PGE 2 induced relaxation at low concentrations (10 )9 -3 · 10 )7 m), which could be inhibited by blocking either the DP or the EP 4 receptor, whereas PGD 2 , PGE 2 , PGF 2a , latanoprost and U46619 induced contraction at high concentrations (10 )6 -10 )5 m), which could be inhibited by blocking the TP receptor. Additionally, blocking of the FP receptor induced a right-shift of latanoprost-induced contraction. Conclusions: Prostaglandins with affinity to DP 1 and EP 4 receptors induce relaxation at low concentrations, and prostaglandins with affinity to TP and FP receptors induce contraction at high concentrations of intraocular porcine ciliary vessels in vitro. The findings may contribute to understanding the regulation of blood flow to the ciliary body.

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Section: Introductionmentioning

confidence: 82%

Dual effect of prostaglandins on isolated intraocular porcine ciliary arteries

Kringelholt

Simonsen

Bek

2012

Acta Ophthalmologica

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“…Prostaglandins are important stimulants of melanogenesis [185] and the FP receptor, to which latanoprost binds, has been localized in all ocular tissue [186] as well as in the hair follicle [146]. In the skin, melanin produced in dermal melanocytes is transported to neighboring keratinocytes in the basal layer of the epidermis [187].…”

Section: Hypertrichosis and Hyperpigmentationmentioning

confidence: 99%

A review of the use of latanoprost for glaucoma since its launch

Digiuni

Fogagnolo

Rossetti

2012

Expert Opinion on Pharmacotherapy

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Latanoprost was the first prostaglandin analog introduced in glaucoma management and it dramatically changed the market of the disease thanks to its efficacy and safety. Conjunctival hyperemia, which is commonly found after latanoprost use, is associated with a minor efficacy and duration of trabeculectomy; yet, from the ophthalmologist's perspective, this side effect seems largely counterbalanced by the high efficacy and safety of this compound. It is always advisable to consider the pro-inflammatory mode of action of latanoprost because this may have negative effects in particular patients (i.e., those with uveitis and cystoid macular edema) for whom caution and close follow-up is necessary.

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“…They act as extracellular hormones through speci®c receptors like EP [1][2][3][4] and FP receptors, localized in ocular tissues (Bazan and Allan, 1997;Resul et al, 1997;Woodward et al, 1997), regulating vascular blood¯ow, production of aqueous humour and BAB. Intraocular tissues appear not to inactivate PGs.…”

Section: Introductionmentioning

confidence: 99%