The molecular basis of high viscosity of monoclonal antibodies (mAbs) at high concentration

Shire, Steven J.

doi:10.1016/b978-0-08-100296-4.00009-9

Cited by 3 publications

(2 citation statements)

References 60 publications

(72 reference statements)

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“…It offers the possibility to work with a wide range of temperatures and concentrations from a small amount of powder [18]. The calculation of the diffusion coefficient D is related to the radius R of the particles by the Stokes-Einstein equation [19]: D = kT/6πηR, where k is the Boltzmann's constant, T the temperature, R the radius of a particle and η the viscosity of the solution (in this study, the viscosity values are: ηethanol = 1.07 × 10 −3 Pa•s and ηisopropanol = 2.37 × 10 −3 Pa•s.) Coatings 2020, 10, x FOR PEER REVIEW 3 of 16 a particle size below 1 µm, which allows a stable and reproducible suspension to be obtained without the use of dispersant.…”

Section: Measurement Of the Particle Size Distributionmentioning

confidence: 99%

Electrophoretic Deposition of 45S5 Bioglass® Coatings on the Ti6Al4V Prosthetic Alloy with Improved Mechanical Properties

et al. 2020

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In this paper, 45S5 Bioglass® coatings were elaborated by electrophoretic deposition (EPD) on the titanium alloy Ti6Al4V. An adequate grinding protocol was developed to obtain a stable suspension of submicrometric particles in isopropanol. The voltage and the deposition time of EPD were optimized. An optimal voltage of 30 V and two deposition times (30 and 90 s) were chosen to obtain two different coatings with thicknesses of 21 and 85 µm, respectively. The as-deposited coatings were thermally treated following a two-step protocol: one hour at 120 °C followed by one hour at 450 °C. The surface morphology and the chemical analysis of the 45S5 Bioglass® coatings were assessed, before and after heat treatment, by scanning electron microscopy associated to X-ray microanalysis (SEM-EDXS). Their structural analysis was performed by X-ray diffraction (XRD). A scratch test study was developed for mechanical properties analysis. The obtained results revealed that the obtained coatings were homogeneous, weakly crystallized with an important compactness. An increase in the critical load LC associated with the cohesive limit of the film (from Lc = 3.39 N to Lc = 5.18 N) was observed when the coating thickness was decreased from 85 to 21 µm. After the thermal treatment, the chemical composition of the coatings was not altered, and their mechanical properties were improved.

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Section: Measurement Of the Particle Size Distributionmentioning

confidence: 99%

Electrophoretic Deposition of 45S5 Bioglass® Coatings on the Ti6Al4V Prosthetic Alloy with Improved Mechanical Properties

et al. 2020

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“…Major traditional viscosity measurement techniques include capillary viscometers, 9,10 rotational viscometers, 11 coaxial cylinder viscometers, 12 falling ball viscometers, 13,14 and vibrational viscometers. 15 These traditional viscometers often use large sample volumes in the millilitre (mL) range to quantify the viscosity of fluids, which is highly undesirable for point of care applications. 16 There is a growing demand for robust, portable platforms to rapidly and cost efficiently measure fluid viscosity at the point of need using sample volumes in the μL to nL range.…”

Section: Introductionmentioning

confidence: 99%