The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma

Abstract

Ameloblastomas are usually benign, locally aggressive neoplasms derived from the epithelial odontogenic tissues. The tumors are known for their propensity for local recurrence. Different mechanisms have been proposed to explain the mechanism behind the pathogenesis of ameloblastoma. The proper understanding of the pathogenetic mechanism involved in ameloblastoma and its proliferation, aids in constituting proper treatment. Molecules involved in the pathogenesis can serve as markers in long term follow-up. Expression of the ameloblastin and amelogenin genes in these tumors play a role and they potentiate their action through different mechanisms. This review focuses on the molecular changes that occur in ameloblastoma which has a bearing upon its treatment and prognosis.

Ameloblastoma

“…Matrix metalloproteinases, triggers mitogens to be released, leading to the proliferation of ameloblastoma cells. [ 14 ]…”

Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update

“…Clinically, it often presents as a slow growing, painless swelling causing expansion of the cortical bone. [ 2 ] Radiographically, it appears as an expansile radiolucency with thinned and perforated cortices, frequently causing root resorption. Large tumors can break through the cortex and involve the soft tissues.…”