The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of “brain–gut–bone” axis

Zhang, Yuan‐Wei; Li, Yingjuan; Lu, Panpan; Dai, Guang-Chun; Chen, Xiang-Xu; Rui, Yun Feng

doi:10.1039/d0fo03468a

Cited by 40 publications

(26 citation statements)

References 134 publications

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“…Many cell signaling cascades necessary for immune cell maturation and function, in part, depend on the gut microbiota for continued optimal function and homeostasis throughout life. Though incredibly complex, the leading hypothesis of recent literature regarding the connection between overall bone health and the gut microbiome centers around T and Th17 immune cells [7,8]. In a T-cell-dependent mechanism, the immune system's reaction to microbiota stimulation increases circulating osteoclastogenic cytokines [8].…”

Section: Human Gut Microbiota: Role In Osteoporosis and Osteoclastogenesismentioning

confidence: 99%

“…Part of the impact of microbial dysbiosis on bone healing and ultimately bone health is mediated by the gut microbiota in the trafficking of TNF + T and Th17 inflammatory cells to the bone marrow as well as influencing the overall inflammatory state of the patient, in what is now being called the "brain-gut-bone" axis [7][8][9]. The inflammatory cells recruited to the wound site by a host of growth factors and chemokines begin laying Int.…”

Section: Introductionmentioning

confidence: 99%

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The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Seely

Kotelko

Douglas

et al. 2021

IJMS

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An expanding body of research asserts that the gut microbiota has a role in bone metabolism and the pathogenesis of osteoporosis. This review considers the human gut microbiota composition and its role in osteoclastogenesis and the bone healing process, specifically in the case of osteoporosis. Although the natural physiologic processes of bone healing and the pathogenesis of osteoporosis and bone disease are now relatively well known, recent literature suggests that a healthy microbiome is tied to bone homeostasis. Nevertheless, the mechanism underlying this connection is still somewhat enigmatic. Based on the literature, a relationship between the microbiome, osteoblasts, osteoclasts, and receptor activator of nuclear factor-kappa-Β ligand (RANKL) is contemplated and explored in this review. Studies have proposed various mechanisms of gut microbiome interaction with osteoclastogenesis and bone health, including micro-RNA, insulin-like growth factor 1, and immune system mediation. However, alterations to the gut microbiome secondary to pharmaceutical and surgical interventions cannot be discounted and are discussed in the context of clinical therapeutic consideration. The literature on probiotics and their mechanisms of action is examined in the context of bone healing. The known and hypothesized interactions of common osteoporosis drugs and the human gut microbiome are examined. Since dysbiosis in the gut microbiota can function as a biomarker of bone metabolic activity, it may also be a pharmacological and nutraceutical (i.e., pre- and probiotics) therapeutic target to promote bone homeostasis.

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Section: Human Gut Microbiota: Role In Osteoporosis and Osteoclastogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Seely

Kotelko

Douglas

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Phytonutrients have also shown some promise in obesity management. As reported by Shiva Ganjali et al in (162), curcumin showed a promising role in obesity management. When obese individuals treated with 1 g curcumin/day in a 4-week long randomized crossover trial, the mean serum IL-1β (p = 0.042), IL-4 (p = 0.008), and VEGF (p = 0.01) were found to be significantly reduced (189).…”

Section: Obesitymentioning

confidence: 63%

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

et al. 2022

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Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota carries a congregation of microbes, the majority and the most widely studied being bacteria in the gut. The adult human gut harbors ginormous inhabitant microbes, and the microbiome accommodates 150-fold more genes than the host genome. Microbial communities share a mutually beneficial relationship with the host, especially with respect to host physiology including digestion, immune responses, and metabolism. This review delineates the connection between environmental factors such as infections leading to gut dysbiosis and NCDs and explores the evidence regarding possible causal link between them. We also discuss the evidence regarding the value of appropriate therapeutic immunomodulatory nutritional interventions to reduce the development of such diseases. We behold such immunomodulatory effects have the potential to influence in various NCDs and restore homeostasis. We believe that the beginning of the era of microbiota-oriented personalized treatment modalities is not far away.

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“…As the human intestine contains a large number of microorganisms, GM stores a huge genome, which is about 150 times the number of human genes. Thus, GM is considered to be the second gene bank of human beings, making it an inseparable part of the human body (10)(11)(12). Moreover, GM plays a crucial role in the health of host from birth, and the interactions between the intestinal epithelial cells, microorganisms and its metabolites are the key mediators between intestinal epithelium and other cell types (13).…”

Section: Introductionmentioning

confidence: 99%

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

Liu

Tian

et al. 2022

Front. Nutr.

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Osteoarthritis (OA) is a common chronic degenerative disease of articular cartilage in middle-aged and older individuals, which can result in the joint pain and dysfunction, and even cause the joint deformity or disability. With the enhancing process of global aging, OA has gradually become a major public health problem worldwide. Explaining pathogenesis of OA is critical for the development of new preventive and therapeutic interventions. In recent years, gut microbiota (GM) has been generally regarded as a “multifunctional organ,” which is closely relevant with a variety of immune, metabolic and inflammatory functions. Meanwhile, more and more human and animal researches have indicated the existence of gut-bone axis and suggested that GM and its metabolites are closely involved in the pathogenic process of OA, which might become a potential and promising intervention target. Based on the close coordination of gut-bone axis, this review aims to summarize and discuss the mechanisms of GM and its metabolites influencing OA from the aspects of the intestinal mucosal barrier modulation, intestinal metabolites modulation, immune modulation and strategies for the prevention or treatment of OA based on perspectives of GM and its metabolites, thus providing a profound knowledge and recognition of it.

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The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of “brain–gut–bone” axis

Abstract: Osteoporosis (OP) is a kind of systemic metabolic disease characterized by the decreased bone mass and destruction of bone microstructure. In recent years, it has become an expectant research trend...

Cited by 40 publications

References 134 publications

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

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