The modifying effect of β-carotene on gamma radiation-induced elevation of oxidative reactions and genotoxicity in male rats

Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

“…Bacterimia may be a cause of mortality secondary to hematopoietic and gastrointestinal damage because antibiotic treatment has been shown to increase the survival of mice irradiated in the LD50/30 range. 42,43 In the present study, the reductions in both Hb level and RBC count in the irradiated group were attributed to the impairment of cell division, obliteration of blood-forming organs, alimentary tract injury, 44 depletion of factors needed for erythroblast differentiation and reticulocyte release from the bone marrow, 45 and the loss of cells from the circulation by hemorrhage or leakage through capillary walls and/or the direct destruction of mature circulating cells. 46 The decrease in all these blood constituents is responsible for anemia.…”

Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro

“…Additional studies also reported an increased frequency of chromosomal alterations in lymphocyte cells (da Silva et al, 2008) The results of this study indicate that neither the antioxidants tested (synthetic betacarotene and acerola fruit pulp) was mutagenic or cytotoxic. It has been shown previously that beta-carotene was not mutagenic toward the bone marrow cells of mice and rats based on the MN test (El-Habit et al, 2000;El-Makawy and El-Ashmaoui, 2003) and was not toxic (2.5, 3.75, and 5.0 mg) when administered to rats (Oliveira et al, 2007). The data from Düsman et al (2012b) corroborate these results because, in natura, acerola pulp (0.2, 0.4 and 5.0 mg/mL) and, frozen pulp (0.2 and 0.4 mg/mL) also showed no mutagenic and cytotoxic activity in bone marrow cells of Wistar rats based on the chromosomal aberration test.…”

Amelioration of Radiation-induced Hematological and Biochemical Alterations by Alstonia scholaris (a Medicinal Plant) Extract

“…In the present study, the reduction in both hemoglobin level and RBC count in the irradiated groups was attributed to the impairment of cell division, obliteration of blood-forming organs, injury to the alimentary tract, 32 depletion of factors needed for erythroblast differentiation and reticulocyte release from the bone marrow, 33 and the loss of cells from the circulation by hemorrhage or leakage through capillary walls and/or the direct destruction of mature circulating cells. 34 Maximum decline in erythrocytes and hemoglobin was observed on the third day following irradiation, which is in agreement with the findings of others.…”