The modified plasma membranes of the transition and horny cells in normal human

Brody, Isser

doi:10.2340/0001555549128138

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1971

2005

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 34 publications

References 10 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Targeted deletion of the sciellin gene resulted in normal development and maturation

Baden

Champliaud²,

Sundberg

et al. 2005

genesis

View full text Add to dashboard Cite

Summary: Sciellin, together with other precursor proteins, was cross-linked by transglutaminase 1 to form the cornified envelope, an essential component of the physical barrier of the epidermis and stratified squamous epithelia. To more fully understand the function of sciellin in cornified envelope formation, we generated sciellin null mice. The mice appeared normal in their development and maturation and there were no structural features that distinguished them from littermate controls. Isolated cornified envelopes appeared normal in structure and were not more fragile to mechanical stress. There was no evidence of decreased barrier function or altered expression of other cornified envelope components. Transgenic mice expressing the repeat domain appeared to have a normal phenotype, like the null, and did not alter endogenous sciellin expression. We conclude that sciellin null mice had no structural anomalies and the transgenic mice did not act as a dominant-negative mutation.

show abstract