The metabolism of the antiviral drug tromantadine (l-adamantyl-2-(2-dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatographyhnass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1-aminoadamantane (amantadine) and l-adamantyl-(2-hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol. ~
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