The modification of resistance to ionizing radiation by humoral agents

A cellular index of sensitivity to ionizing radiation. The sensitization response

“…These same compounds, i.e., stilbes trol, testosterone propionate, and progesterone elicit SR when given to animals. Radiation induces a cytoplasmic vacuolization in the basal cells that resembles that seen in SR. 4. T h e correlation between SR, radiation reaction, and the ultimate cure of the patients suggests a common factor.…”

Effectiveness of Radiotherapy in Cancer of the Uterine Cervix*

“…The administration of certain substances, e.g. , testosterone propionate or alpha‐tocopherol, has been found to make animals abnormally sensitive to total body radiation, as indicated by an increased death rate (13). Accordingly, a cervical cancer patient was observed during the early phase of her radiotherapy and recognized as a “poor response.” She was then started on testosterone propionate, 25 mg. three times a week intramuscularly, which was continued during the remainder of her radiotherapy.…”