The Modern Chemical Theory of Ovarian Cancer Origin

Abstract

Because of its histological and embryological complex development, the ovary can be the source of a large variety of tumors, ovarian cancer being the fifth female neoplasia as a frequency. A major clinical significance is that the ovarian tumor is asymptomatic for a long period of time.Ovarian proliferative pathology raises a number of important issues from both theoretical and practical point of view. The change in the therapeutic attitude, especially in the areas of surgery and chemotherapy, has led in the last decades to an improvement in the survival rate. Our retrospective study included the analysis of 64 patients with ovarian cancer. Ovarian neoplasms should have a multidisciplinary approache with individualized treatment for each patient. The long-term survival remains, however, the detection of the tumor at an early stage, the undetectment in the initial stages leading to a survival rate of 5 years less than 20%.

Importance of Surgical Treatment in Ovarian Neoplasm

“…Of all patients with intestinal occlusion, about 20% of the cases were found to be inoperable. However, the vast majority of patients had a survival rate of less than 1 year [55][56][57].…”

The Concept of Debulking in Ovarian Cancer

“…In the current speciality literature, it is mentioned that the primary most important prognosis factor is the type of surgery, more exactly: as the first surgery is more radical (residual tumoral after surgery macroscopically absent) as the chance of survival is better. [19][20][21][22].…”

“…In this regard, Bristow et al were able to demonstrate in a study of 6885 patients operated for stage III / IV ovarian neoplasm FIGO that patients who received complete cytoreduction had a 5.5% increase in the median survival rate, which we can translate by an increase of 2-3 months, compared to the patients who have undergone optimal surgery [8][9][10].…”

Preserving Fertility in Ovarian Cancer

“…Young women, who were operated conservatively for ovarian tumors well differentiated in stage IA, should also be informed about the recommendation of performing total hysterectomy with contralateral anexectomy, after the age of 35 years or earlier if preservation of fertility is no longer a goal [20][21][22][23].…”