Introducere: Cancerul ovarian reprezintă cea mai letală afecţiune onco-ginecologică. Marea majoritate a pacientelor se diagnostichează în stadii avansate de boală, în care rata recidivelor este crescută, iar şansa de supravieţuire la 5 ani este sub 45%. Scopul: evaluarea unor corelaţii ale supravieţuirii globale cu caracteristici clinico paraclinice, tumorale sau de tratament pentru identificarea factorilor de prognostic, la pacientele cu cancer ovarian avansat -stadiile III şi IV FIGO. Material şi Metodă: Am efectuat o analiză retrospectivă la 65 paciente cu cancer ovarian avansat -stadiile III şi IV FIGO operate în perioada 2010-2018, cu o perioadă de urmărire de cel puţin un an. S-au efectuat corelaţii cu caracteristici clinicoparaclinice, tumorale sau de tratament cu supravieţuirea globală. Rezultate: În analiza statistică univariată de supravieţuire se obţine o asociere semnificativă statistică cu prezenţa durerilor pelvine la internare (p_value=0.033744), in cadrul substadiului III (p_value = 0.007595, respectiv p_value=0.022090), cu tipul de citoreducţie (p_value = 0.035554), cu complicaţiile postoperatorii (p_value = 0.000685) în cadrul subtipurilor histopatologice (p_value = 0.046266), cu tratamentul adjuvant (p_value = 0.000083). Analiza de regresie multivariata Cox a arătat că chimioterapia adjuvantă (HR=0.046, 95%CI = (0.008, 0.261), (p_value = 0.000492), citoreducţia suboptimală (HR= 0.346, 95%CI = (0.140, 0.853), (p_value = 0.021219) şi
The present study aims at determining on the one hand the growth differentiation factor 15 significance as possible risk biomarker for this condition and, on the other hand, the degree of correlation between its serum concentration and the class of inotropism deficit.The value of the current research stems from the very selected theme, the activity of GDF-15, member of the superfamily of cytokines TGF-b recognized as having implication in atherosclerosis, but almost unexplored as role in the myocardiumremodeling processes, more precisely in fibrosis.
In the last decades, by improving the oncological treatment, the life expectancy of the adolescent patients with ovarian cancer has been increased and more than that they have succeeded by a real chance of obtaining a future pregnancy. Thus, the problem of preserving fertility becomes paramount both for patients who have suffered from an oncological disease and for those up to the age of 40 who have fertility problems.
Ovarian neoplasm is extremely aggressive and has a high mortality rate among affected women; therefore, the crucial role of screening tests is easy to understand. Prevention and early diagnosis should be essential priorities in the management of this malignancy. Since a complete and correct clinical examination can select the cases that require specialized investigations, we can consider it a first screening test.
Background: Patients with chronic pancreatitis can suffer from a range of intense pain, as well as problems related to the functioning of the digestive organs, the evaluation of the quality of life can provide valuable information about the level of physical and emotional discomfort felt by the patients after the surgical intervention. Methods: A prospective study was carried out in the period 2014-2020 in which 113 patients with benign pancreatic pathology treated surgically admitted to the CF2 Clinical Hospital in Bucharest were included. For this study, the statistical method of simple linear regression was applied. Results: Patients' quality of life can also be influenced by the level of social support and medical care they receive. A strong support network, which can provide emotional and practical support, as well as access to appropriate and specialist medical care, can play an important role in managing symptoms and improving patients' quality of life. Conclusions: Although patients in this study experienced significant improvement in symptoms and ability to perform daily activities, it is important to pay attention to and manage persistent symptoms and postoperative complications to ensure the best possible quality of life.
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