The mode of action of Zaluzanin C, an inhibitor of translation in eukaryotes

Santamaría, F.; Zaera, E.; Vázquez, David; Jiménez, Antonio Moreno

doi:10.1016/0006-291x(84)90379-6

Cited by 5 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro protein synthesis was blocked by zaluzanin C (147) and the study of the effects of the drug on resolved model systems indicates that it inhibits enzymic translocation of peptidyl-tRNA specifically (Santamaria et al, 1984). The Acyl-CoA cholesterol acyltransferase (ACAT), diacylglycerol acyltransferase (DGAT) and farnesyl-protein transferase (FPTase) inhibitory effects of the roots of Ixeris dentata forma albida were investigated and one of the active compounds was identified as zaluzanin C (147) (Bang et al, 2004).…”

Section: Other Activitiesmentioning

confidence: 99%

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

View full text Add to dashboard Cite

Section: Other Activitiesmentioning

confidence: 99%

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

View full text Add to dashboard Cite

“…possess relevant biological activity. Thus, for example, zaluzanin A ( 1 ) induced relaxation in KCl-induced contraction in rat uterine smooth muscle and reduced human sperm motility in vitro 15 ; zaluzanins 3 and 4 exhibited antileukemic and anticancer properties 10,16,17 ; and 4 was also reported as an antifungal agent. 18 Ivalin ( 6 ) showed significant cytotoxic activity against several murine and human tumor cell lines, comparable to that of cisplatin.…”

Section: Resultsmentioning

confidence: 99%

“…In an interesting study on flavonoids in Zaluzania spp., 20 Olsen and Mabry (1980) found that various species in this genus produce about 20 compounds, 13 of which were characterized as methyl ethers and/or glycosides of quercetin (13)(14)(15)(16)(17)(18)(19)(20), kaempferol (21,22), and patuletin (23,24). Jaceidin (25) was also identified (Figure 2).…”

Section: Flavonoidsmentioning

confidence: 99%

Chemical Composition of Plants of the Genus Zaluzania

Torres-Valencia,

Zeferino-Díaz,

Ortiz-León

et al. 2023

Natural Product Communications

View full text Add to dashboard Cite

The chemical structure of compounds identified in species of the genus Zaluzania is reported herein, highlighting the contributions by Professor Pedro Joseph-Nathan to the chemistry of these plants. Although 36 names have been proposed for Zaluzania, only 14 species are currently accepted in the genus, and they are reported to be a rich source of sesquiterpene lactones and flavonoids. Their essential oils also contain several terpenoids, especially ent-kaurene-type diterpenes. In addition, we identified the guaianolides zaluzanin A and zaluzanin B, zaluzanin C, and zaluzanin D, and the eudesmanolides ivalin and ivalin acetate as the major constituents in infusions of aerial parts of Zaluzania augusta, Zaluzania parthenioides, and Zaluzania triloba, respectively. These sesquiterpene lactones were characterized by their physical and spectroscopic data, including 1H and 13C nuclear magnetic resonance (NMR). Likewise, the structures of zaluzanins C and ivalin were confirmed by X-ray diffraction analysis. The presence of guaianolides in Z. parthenioides and eudesmanolides in Z. triloba could be used as a biomarker to differentiate these 2 species, which were previously considered synonymous.

show abstract

“…Heteronuclear multiple quantum correlation Besides the importance chemosystematic, 27 sesquiterpene lactone posseses a wide spectrum of biological activity. 28 Zaluzanin C, Zaluzanin D and its derivatives have shown several biological activities, such as activity against the P 388 lymphocytic leukemia in vitro, 29,30 antifungal activity, 31,32 inhibitory activity on nitric oxide production and nuclear fator KB, 33 inhibitory activity on ethanol absorption. 34 On the basis of the above data, we conclude that M. hoehnei belongs to the Brazilian Mikania species groups, which produce sesquiterpene lactones.…”

Section: Resultsmentioning

confidence: 99%