PROBLEMTo distinguish patients with multiple sclerosis (MS) from those with nonorganic pseudoneurologic (P) disorders, two PIIMP1 indices-the 17-item pseudoneurologic (PsN) scale'', ') and the 7-item complex of Hovey(2. 3)-have been used. Based on our experience with 70 patients with multiple sclerosis and 61 patients with pseudoneurologic disorders, this paper evaluates the usefulness of these two indices.Shaw and Matthews ( 7 ) and Shaw@) reported that the 17-item pseudoneurologic scale differentiated pseudoneurologic and neurologic groups of disorders. By a pseudoneurologic disorder, these authors meant a disorder with symptoms that suggested organic brain dysfunction but with a final diagnosis of psychiatric condition. Shaw and J . l a t t h e w~(~) identified 81% of such patients; they had only 25% false positives, and in a cross-validation that used the same cut-off point of 7 or more items, they identified 67% of the patients with pseudoneurologic disorders and 22% false positives.Dodge and Kolstoe('), who used the same cut-off score of 7 or more scorable items, reported that the PsN scale identified 10 of 14 patients with early multiple sclerosis and 11 of 13 patients with conversion hysteria.Hovey(20 3 , reported on five and then an additional two items. These items differentiated in repeated samples, first between patients with central nervous system disease and those without central nervous system disease and second, between patients with and without R4S. Dodge and Kolstoe'l) reported that the original five items were not useful to differentiate early RIS and conversion hysteria. Their study, however, had four limitations: the small sample of 14 MS and 13 conversion hysteria patients; the lack of data with regard t o the disability ratings; the mixing of sexes in the analysis; and the variability of age. The latter two criticisms are a direct result of limited sample size. A fifth limitation is the omission of the additional two items reported by Hovey C3) as assisting in differentiation.The present research has these advantages: increased sample size of both MS and P patients, which makes possible sex and age evaluation; the incorporation of the additional two Hovey items; the use of a widely accepted neurologic disability rating scale for MS patients; and information on the duration of symptoms.
METHODSDiagnostic Categories: Multiple Sclerosis. The 70 patients with MS included 28 men and 42 women. Table 1 provides data of ratings for disability (10-point scale; 0-9) and age means. These Ss were rated for disability according t o the system of K~r t z k e (~8 5 ) . Of the 70 patients, 30 were given a rating of 1; 13 were rated 2; 8 were rated 3; 6 were rated 4; 4 were rated 6; 8 were rated 7; 1 patient was rated 0 (normal neurologic examination) ; and there were no patients with ratings of 5, 8, and 9.Pseudoneurologic Disorder. The 61 patients in the P group included 25 men and 36 women. This group comprised patients who were referred for neurologic examination, but in whom no neurologic and usually ...