The mismatch negativity (MMN): towards the optimal paradigm

Näätänen, Risto; Pakarinen, Satu; Rinne, Teemu; Takegata, Rika

doi:10.1016/j.clinph.2003.04.001

Cited by 599 publications

(470 citation statements)

References 13 publications

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“…Based on these results we can conclude that the 'less meaningful' pitch contrasts are not suppressed by the presence of the 'more meaningful' phonemic deviants in the same sequence. This is in accordance with earlier studies, revealing that the presence of multiple deviants does not influence the MMNs to meaningless stimuli in a passive oddball paradigm (Deacon et al, 1998;Grimm and Schröger, 2007;Molholm et al, 2004;Näätänen et al, 2004) or to meaningful stimuli in an active distraction paradigm (Grimm et al, 2008). According to our results, these findings can be extended to the MMNs to meaningful stimuli when a passive oddball paradigm is used.…”

Section: Discussionsupporting

confidence: 93%

“…They found that the MMNs in the multi-deviant condition were similar in magnitude to the corresponding MMNs in the single-deviant condition. These results have since been replicated by other studies (Molholm et al, 2004;Näätänen et al, 2004). In addition, Grimm et al (2008) showed that in an active distraction paradigm with single and multiple deviants, phonemic changes elicited MMNs that were similar in magnitude.…”

Section: Introductionsupporting

confidence: 66%

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Towards neurophysiological assessment of phonemic discrimination: Context effects of the mismatch negativity

Davids

Brink

Turennout

et al. 2009

Clinical Neurophysiology

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a b s t r a c tObjective: This study focusses on the optimal paradigm for simultaneous assessment of auditory and phonemic discrimination in clinical populations. We investigated (a) whether pitch and phonemic deviants presented together in one sequence are able to elicit mismatch negativities (MMNs) in healthy adults and (b) whether MMN elicited by a change in pitch is modulated by the presence of the phonemic deviants. Methods: Standard stimuli [i] were intermixed with small, medium or large pitch deviants or with pitch deviants of the same magnitude together with small and large phonemic deviants, [y] and [u], respectively. Results: When pitch and phonemic deviants were presented together, only the large pitch and phonemic contrasts elicited significant MMNs. When only pitch deviants were presented, the medium and large pitch contrasts elicited significant MMNs. The MMNs, in response to the medium and large pitch contrasts, were of similar magnitude across the two contexts. Conclusions: Pitch and phonemic deviants can be tested together provided the pitch contrast is relatively large. Significance: A combined neurophysiological test of phonemic and pitch discrimination, as measured by the MMN, is a time-effective tool that may provide valuable information about the underlying cause of poorly specified phonemic representations in clinical populations.Crown

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Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 66%

Towards neurophysiological assessment of phonemic discrimination: Context effects of the mismatch negativity

Davids

Brink

Turennout

et al. 2009

Clinical Neurophysiology

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“…14,[41][42][43][44][45][46][47][48] Such statistical proof is generally done with a t test based on the mean MMN amplitude in subjects. Table 1 thus shows that MMNs elicited for duration and frequency deviations were statistically demonstrated in the experiment group -(C)APD -and the control group.…”

Section: Discussionmentioning

confidence: 99%

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

Roggia

Colares

2008

Rev. Bras. Otorrinolaringol.

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O Mismatch Negativity (MMN) é um potencial evocado auditivo de longa latência que fornece uma medida objetiva das habilidades de discriminação e memória sensorial auditiva. Assim, pode ser utilizado como uma avaliação eletrofisiológica do processamento auditivo (central). OBJETIVO: Estudar o MMN em pacientes com Distúrbios do Processamento Auditivo (Central) - DPA(C). FORMA DO ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram avaliados oito sujeitos com DPA(C), na faixa etária de nove a 14 anos, bem como um grupo controle. O MMN foi eliciado para estímulos tonais (tone bursts) diferindo quanto à freqüência (MMNf - estímulo padrão: 750Hz e estímulo diferente: 1000Hz ), bem como quanto à duração (MMNd - estímulo padrão: 100 ms e estímulo diferente: 50 ms; na freqüência de 1000Hz). RESULTADOS: A presença do MMNf e do MMNd foi comprovada estatisticamente em ambos os grupos estudados. Não foram constatadas diferenças significantes estatisticamente entre os valores de latência e de amplitude do MMNf e do MMNd obtidos nos dois grupos. Também não foram verificadas diferenças significantes estatisticamente entre o MMNf e o MMNd em nenhum dos grupos estudados. CONCLUSÃO: Os sujeitos com DPA(C) avaliados não apresentaram alterações no MMNf, nem no MMNd.

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“…Näätänen et al (2004) 19 analyzed seven subjects with 25 years. The ages of the subjects studied by the aforementioned authors match the ages of the subjects in our study, which varied from 18 years and 2 months to 24 years and 11 months; the females were between 20 years and 5 months and 24 years and 11 months; and from 18 years and 2 months to 23 years and 11 months were males (Table 1 and Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Verificação das respostas do mismatch negativity (MMN) em sujeitos adultos normais

Brossi¹,

Borba²,

Garcia

et al. 2007

Rev. Bras. Otorrinolaringol.

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Mi smatch Negativity (MMN) is used to evaluate the central auditory system. Aim: to characterize the MMN, in normal subjects. Materials and methods: prospective study, 12 subjects, six males and six females, between the ages of 18 and 24. "Mann-Whytnei" test. Exams: Pure Tone Audiometry (PTA), Tympanometry, Otoacoustic Emissions and Short and Long Latency Auditory Potentials (MMN). Results: in MMN variable amplitude, the mean value was of -2.757 µV and -3.548 µV, CZA1 and CZA2; of 1.435 µV and -1.867 µV, CZA1 and CZA2. In variable and medium latency, we found in 150.7ms and 153.2ms, CZA1 and CZA2; in 170.4ms and 184.0ms, CZA1 and CZA2 -for females and males respectively. Conclusion: related to latency, there was significant statistical difference between the genders in relation to CZA1 and CZA2; and it was lower for females and higher for males.

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The mismatch negativity (MMN): towards the optimal paradigm

Cited by 599 publications

References 13 publications

Towards neurophysiological assessment of phonemic discrimination: Context effects of the mismatch negativity

Towards neurophysiological assessment of phonemic discrimination: Context effects of the mismatch negativity

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

Verificação das respostas do mismatch negativity (MMN) em sujeitos adultos normais

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