The minipig in toxicology

Svendsen, Ove

doi:10.1016/j.etp.2006.03.003

Cited by 143 publications

(101 citation statements)

References 8 publications

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“…The differences are the interfollicular muscle, the distribution and function of apocrine versus eccrine sweat glands, thickness of the stratum corneum (SC), the basement membrane epitopes, and cytochrome P-450 biotransformation isoenzymes (Svendsen 2006; M. M. Swindle et al 2012). …”

Section: Comparative Anatomy and Functionmentioning

confidence: 99%

“…Using these miniature breeds allows investigators to conduct experiments in mature (rather than pediatric) animals with a consistent size and health status. Each breed may be utilized in some aspect of dermal toxicology (Brown, Stricker-Krongrad, and Bouchard 2013;Gad, Stricker-Krongrad, and Skaanild 2015;Svendsen 2006;M. M. Swindle et al 2012).…”

Section: Dermal Modelsmentioning

confidence: 99%

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The Miniature Swine as a Model in Experimental and Translational Medicine

2016

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The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are regularly used for studies designed to assess efficacy and safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to rodents, canines, or nonhuman primates. Translational preclinical swine study data presented here support the current understanding that miniature swine are the animal model of choice for the assessment of drugs targeting endocrine, dermal, and ocular disorders. Because research investigators need to be familiar with some of the important features of the models developed in the miniature swine in order to place clinical and experimental findings in their proper perspective, relevant references and data from these models will be presented, compared, and partially illustrated.

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Section: Comparative Anatomy and Functionmentioning

confidence: 99%

Section: Dermal Modelsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

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“…In recent years, miniature pigs have often been used as laboratory animal models for medical research (Van Dorp et al, 1998;Polejaeva et al, 2000;Schwartz and Kagan, 2002;Xu et al, 2003;Watanabe et al, 2004;Svendsen, 2006) because they are smaller than pigs (livestock) and because the morphology and size of their organs are similar to those of humans (Bustad, 1966). Miniature pigs are also frequently used in the dental field for basic research.…”

mentioning

confidence: 99%

Postnatal Mandibular Cheek Tooth Development in the Miniature Pig Based on Two‐Dimensional and Three‐Dimensional X‐Ray Analyses

Ide

Nakahara

Nasu

et al. 2013

The Anatomical Record

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The miniature pig is a useful large laboratory animal model. Various tissues and organs of miniature pigs are similar to those of humans in terms of developmental, anatomical, immunological, and physiological characteristics. The oral and maxillofacial region of miniature pigs is often used in preclinical studies of regenerative dentistry. However, there is limited information on the dentition and tooth structure of miniature pigs. The purpose of this study was to examine the time-course changes of dentition and tooth structure (especially the root) of the miniature pig mandibular cheek teeth through X-ray analyses using soft X-ray for twodimensional observations and micro-CT for three-dimensional observations. The mandibles of male Clawn strain miniature pigs (2 weeks and 3, 5, 7, 9, 11, 14, 17, and 29 months of age) were used. X-ray analysis of the dentition of miniature pig cheek teeth showed that the eruption pattern of the miniature pig is diphyodont and that the replacement pattern is vertical. Previous definitions of deciduous and permanent teeth often varied and there has been no consensus on the number of teeth (dentition); however, we found that three molars are present in the deciduous dentition and that four premolars and three molars are present in the permanent dentition. Furthermore, we confirmed the number of tooth roots and root canals. We believe that these findings will be highly useful in future studies using miniature pig teeth.

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“…Miniature pigs such as Göttingen are well known as one of the ideal experimental animals because of their similarities to humans including skin, cardiovascular, respiratory, metabolic, gastrointestinal systems and so on Forster et al, 2010;Laursen et al, 2011;Svendsen, 2006). However, it has been difficult to use not only regular pigs but also miniature pigs for obtaining in vivo proof, since they require much larger dose of a test article than in dogs and monkeys which have been used as non-rodent experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of <i>microminipig</i> as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies

et al. 2017

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-We tried to establish the halothane-anesthetized microminipigs as an alternative animal model for non-clinical toxicity and/or safety pharmacology studies. In order to characterize the halothane-anesthetized microminipigs, we firstly clarified the effects of halothane anesthesia on their cardiovascular system (n = 5). Then, we examined the cardiovascular effects of dl-sotalol in doses of 0.1, 0.3 and 1 mg/kg, i.v. on the halothane-anesthetized microminipigs (n = 6). Induction of the halothane anesthesia by itself prolonged the QT interval as well as QTcF, suggesting that the halothane anesthesia can reduce the cardiac repolarization reserve in microminipigs like in dogs. dl-Sotalol showed more potent negative chronotropic, dromotropic and hypotensive effects together with repolarization delay in microminipigs than in dogs, although each cardiovascular response to dl-sotalol was directionally similar between them, suggesting greater basal sympathetic tone and/or smaller volume of distribution of the drug in microminipigs than in dogs. Analyses of proarrhythmic surrogate markers indicate that T peak -T end and short-term variability of QT interval may be more sensitive to detect the dl-sotalol-induced direct electrophysiological changes in microminipigs than in dogs, but its reverse will be true for J-T peak c. Thus, these results may help better understand the drug-induced cardiovascular responses in microminipigs.

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The minipig in toxicology

Cited by 143 publications

References 8 publications

The Miniature Swine as a Model in Experimental and Translational Medicine

The Miniature Swine as a Model in Experimental and Translational Medicine

Postnatal Mandibular Cheek Tooth Development in the Miniature Pig Based on Two‐Dimensional and Three‐Dimensional X‐Ray Analyses

Pharmacological characterization of <i>microminipig</i> as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies

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