The mid-infrared spectroscopy: A novel non-invasive diagnostic tool for NASH diagnosis in severe obesity

Anty, Rodolphe; Morvan, Marie; Corvec, Maëna Le; Canivet, Clémence M.; Patouraux, Stéphanie; Gugenheim, Jean; Bonnafous, Stéphanie; Bailly-Maître, Béatrice; Sire, Olivier; Tariel, Hugues; Bernard, Jérôme; Piche, Thierry; Loréal, Olivier; Aron‐Wisnewsky, Judith; Clément, Karine; Tran, Albert; Iannelli, Antonio; Gual, Philippe

doi:10.1016/j.jhepr.2019.09.005

Cited by 11 publications

(8 citation statements)

References 40 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While intriguing, this study could potentially benefit from a different and less complicated method of analysis to reach higher classification results; however, based on the sample size, this study provides one of the most realistic evaluations of IR spectroscopy for identifying diabetes. 85 In a related manner, Bernardes-Oliveira et al 86 utilized ATR FT-IR to investigate blood plasma obtained from 50 healthy pregnant women and 50 pregnant women with gestational diabetes mellitus. Several different chemometric methods were employed for separating the two groups, including LDA, quadratic discriminant analysis, and SVM.…”

Section: General Application Of Chemometric Methods For Indicating Diabetes Within Various Biological Samplesmentioning

confidence: 99%

Vibrational Spectroscopy for Detection of Diabetes: A Review

Ralbovsky

Lednev

2021

Appl Spectrosc

View full text Add to dashboard Cite

Type II diabetes mellitus (T2DM) is a metabolic disorder that is characterized by chronically elevated glucose caused by insulin resistance. Although T2DM is manageable through insulin therapy, the disorder itself is a risk factor for much more dangerous diseases including cardiovascular disease, kidney disease, retinopathy, Alzheimerâs disease, and more. T2DM affects 450 million people worldwide and is attributed to causing over 4 million deaths each year. Current methods for detecting diabetes typically involve testing a personâs glycated hemoglobin levels as well as blood sugar levels randomly or after fasting. However, these methods can be problematic due to an individualâs levels differing on a day-to-day basis or being affected by diet or environment, and due to the lack of sensitivity and reliability within the tests themselves. Vibrational spectroscopic methods have been pursued as a novel method for detecting diabetes accurately and early-on in a minimally invasive manner. This review summarizes recent research, since 2015, which has used infrared or Raman spectroscopy for the purpose of developing a fast and accurate method for diagnosing diabetes. Based on critical evaluation of the reviewed work, vibrational spectroscopy has the potential to improve and revolutionize the way diabetes is diagnosed, thereby allowing for faster and more effective treatment of the disorder.

show abstract

Section: General Application Of Chemometric Methods For Indicating Diabetes Within Various Biological Samplesmentioning

confidence: 99%

Vibrational Spectroscopy for Detection of Diabetes: A Review

Ralbovsky

Lednev

2021

Appl Spectrosc

View full text Add to dashboard Cite

show abstract

“…Mid-infrared (MIR) spectroscopy measures the vibrational interactions between a sample and mid-infrared light. The MIR spectrum of a patient’s biofluid may constitute a metabolic fingerprint that can be used for diagnostic purposes [ 8 ]. Several mid-infrared spectroscopy techniques have been developed.…”

Section: Introductionmentioning

confidence: 99%

Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study

Farrugia

Corvec

Renou³

et al. 2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. Patients and Methods: Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86). Results: Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. Conclusion: The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.

show abstract

“…As this wavelength range hosts the vibrational and rotational resonances of a large variety of molecules, this so called "fingerprint region" can be used to unambiguously detect a broad number of substances such as carbon dioxide (CO 2 ), carbon monoxide (CO), methane (CH 4 ), ammonia (NH 3 ) or nitrous oxide (N 2 O) [2]. The strong and specific absorption of these molecules in the mid-IR range can thus be used to detect small analyte concentrations, potentially up to parts per billion (ppb), having a high impact in sensing and monitoring applications in fields like environmental monitoring [3], hazard detection [4], industrial process control [5], astronomy [6] or non-invasive medical diagnostics [7]. Moreover, the use of mid-IR PICs has also been proposed as a powerful solution to overcome several major existing drawbacks in other important areas such as thermal imaging [8] or optical communications [9,10].…”

Section: Introductionmentioning

confidence: 99%

Ge-rich graded SiGe waveguides and interferometers from 5 to 11 µm wavelength range

Montesinos‐Ballester¹,

Vakarin²,

Liu³

et al. 2020

Opt. Express

View full text Add to dashboard Cite

The mid-infrared (mid-IR) wavelength range hosts unique vibrational and rotational resonances of a broad variety of substances that can be used to unambiguously detect the molecular composition in a non-intrusive way. Mid-IR photonic-integrated circuits (PICs) are thus expected to have a major impact in many applications. Still, new challenges are posed by the large spectral width required to simultaneously identify many substances using the same photonic circuit. Ge-rich graded SiGe waveguides have been proposed as a broadband platform approach for mid-IR PICs. In this work, ultra-broadband waveguides are experimentally demonstrated within unprecedented wavelength range, efficiently guiding light from 5 to 11 µm. Interestingly, losses from 0.5 to 1.2 dB/cm are obtained between 5.1 and 8 µm wavelength, and values below 3 dB/cm are measured from 9.5 to 11.2 µm wavelength. An increase of propagation losses is seen between 8 and 9.5 µm; however, values stay below 4.6 dB/cm in the entire wavelength range. A detailed analysis of propagation losses is reported, supported by secondary ion mass spectrometry measurement, and different contributions are analyzed: silicon substrate absorption, oxygen impurities, free carrier absorption by residual doping, sidewall roughness and multiphonon absorption. Finally, Mach-Zehnder interferometers are characterized, and wideband operation is experimentally obtained from 5.5 to 10.5 µm wavelength.

show abstract

The mid-infrared spectroscopy: A novel non-invasive diagnostic tool for NASH diagnosis in severe obesity

Cited by 11 publications

References 40 publications

Vibrational Spectroscopy for Detection of Diabetes: A Review

Vibrational Spectroscopy for Detection of Diabetes: A Review

Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study

Ge-rich graded SiGe waveguides and interferometers from 5 to 11 µm wavelength range

Contact Info

Product

Resources

About