The addition of interstitial elements often has a significant impact on the macroscopic performances of structural alloys. Here, we report a systematic study on the microstructure, corrosion behavior and mechanical properties of a series of as-cast Ti-0.3Mo-0.8Ni-xC (x = 0.09, 0.12 and 0.15 wt.%) alloys. A typical basket-weave microstructure appears in all specimens, characterized by the lamellar α-phase and intergranular retained β-phase without TiC precipitates existed in prior β grain boundary. Based on the electrochemical and immersion tests, doping with C element can significantly improve the corrosion resistance of TA10 alloys; with increasing the carbon content, the corrosion current density decreases from 13.58 to 3.54 μA·cm-2, the corrosion potential increases from -0.318 to -0.237 V vs. SCE, the corrosion rate reduces from 15 mm/a to 7.5 mm/a, along with an elevated pitting and crevice corrosion resistance. Moreover, the mechanical properties of TA10 alloys, such as the strength and hardness, can also be enhanced via C alloying. Our results indicate that the addition of interstitial elements should be a potential effective mean to accommodate the comprehensive performances of TA10 alloys.