The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

Comparative Cross-sectional Quantitative Study of Health Status among Consumers of Bitter Kola in Igbuzor Community Living in Oshilmili North Local Government Area of Delta State

“…[35] One study also found that the high rated anti-virus and bacterial activities of bitter kola may be attributed to its active compound known as a dimeric flavonoid, which is one of phytochemicals compounds isolated from bitter kola. [17] Another study demonstrated that Baicalin, a flavonoid isolated from Scutellaria baicalensis (Lamiaceae), inhibits HIV-1 infection and replication. Baicalein and other flavonoids such as Robusta flavone and hinokiflavone have been shown to inhibit HIV-1 and reverse transcriptase.…”

“…[39] Similarly, flavonoid, which is one of the phytochemicals compounds isolated from bitter kola, inhibit the enzymes involved in ROS. [17] Flavonoids possess many biochemical properties, but the best-described property of almost every group of flavonoids is their capacity to act as antioxidants. [40] One study also cited by Kumar and Pandey, (2013) identified several mechanisms by which flavonoids act to prevent cancer.…”

“…[15] Another study showed that bitter kola which has an abundance of flavonoid prevents neuronal damage in the malnourished mice. [17] The main reason given for growing global acceptance of traditional remedies is the dissatisfaction with the results from orthodox pharmaceutical drugs and the belief that plant medicines might be effective in the treatment of certain diseases where the orthodox medicines have proven to be ineffective or with inherent adverse side effects. [18] In other words, there is a growing acceptance of plant medicine in both developed and developing countries for all kinds of conditions and situations where conventional treatment options have been limited.…”

Evaluation of Different Fractions of Garcinia kola Extracts against Multidrug Resistant Clinical Bacterial and Fungal Isolates

“…11 The antibacterial biflavonoid of chewing Garcinia kola Kennel have also been isolated and characterised. 12 Also, the extracts of the Garcinia seeds are reported by Tchimene et al 13 and Ajayi et al 14 to have anti-inflammatory effects. These reports have therefore confirmed the reasons why the plant was named "wonder plant" due to its medicinal importance.…”

Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders

“…Clinical efficacy of Garcinia kola in the treatment of knee osteoarthritis was attributed to its analgesic or anti-inflammatory property (Adegbehingbe et al, 2008). Kolaviron also protected pheochromocytoma (PC) 12 cells and human dopaminergic SH-SY5Y cells exposed to atrazine (Abarikwu et al, 2011a,b) Prior administration of Garcinia kola aqueous extract (200 mg/kg for 7 days) offered hippocampus and cerebellum neuronal protection in 3-NP-induced malnourished mice (Ajayi et al, 2011).…”