The Microsponge® Delivery System (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives

Embil, Koral; Nacht, Sergio

doi:10.3109/02652049609026042

Cited by 144 publications

(73 citation statements)

References 4 publications

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“…After sometime, due to the contact generated, a response occurs 67 . Microsponges which consist of non-collapsible structures with porous surface through active ingredients are released in a controlled manner 68 . The microsponge particles have open structures and the active agent is free to move until equilibrium is reached when the vehicle becomes saturated.…”

Section: Microspongesmentioning

confidence: 99%

Advanced Trends in Treatment of Wounds

Miranda

Ganga

2016

Current Science

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There are a wide variety of dressing techniques available for the management of both acute and chronic wounds. The primary objective in both the cases is to achieve a healed wound. An ideal dressing material should accelerate wound healing and reduce loss of necessary fluids from the wound, and also help minimize pain and infection. The present trend is to promote the concept of moist wound healing. This article emphasizes on the importance of assessment of the wound, the volume of drainage fluid, amount of damage, presence of infection and location of wound for optimal wound healing.

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Section: Microspongesmentioning

confidence: 99%

Advanced Trends in Treatment of Wounds

Miranda

Ganga

2016

Current Science

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“…5,22 And later, the Retin-A microsponges (0.1% or 0.04% tretinoin) and Carnac microsponges (0.5% 5-flurouracil) for acne and actinic keratoses respectively were approved by Food and Drug Administration (FDA). Afterward, microsponges for topical skin-target drug delivery are widely developed and utilized in topical drug delivery system, such as mupirocin microsponge, hydroxyzine hydrochloride microsponge, paeonol microsponge and so on.…”

Section: Initial Discoveriesmentioning

confidence: 99%

“…2 Additionally, TDDS permits the permeation of drugs across the skin and into the systemic circulation which avoids the hepatic first-pass effect observed in the course of oral administration and inconvenience of frequent parenteral administration. 3 As a new drug carrier of TDDS, Microsponges are mostly used for topical [4][5][6][7][8][9][10] and oral administration. [11][12][13][14][15] For other topical delivery systems, the traditional delivery systems are required of frequent dosing to keep relatively stable local concentrations of effective constituent for therapeutic effectiveness because of low effectiveness.…”

Section: Introductionmentioning

confidence: 99%

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Toward Application of Microsponges in Transdermal Drug Delivery System

Hong¹,

Chen²,

Xiang³

et al. 2015

MOJBB

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Abbreviations: TDDS, transdermal drug delivery system; FDA, food and drug administration; EC, ethyl cellulose; BPO, benzoyl peroxide; SEM, scanning electron microscopy; AUC, area under the curve; EE, entrapment efficiency; DSC, differential scanning calorimetry; MED, minimal erythemal dose; SPF, sun protection factor IntroductionCompared with drug dosage forms for oral and parenteral administration, Transdermal drug delivery system (TDDS) can minimize and avoid some restrictions relating to dosage forms effectively. Due to the conventional delivery systems suffering from certain restrictions like Peak and Valley phenomenon i.e., they show fluctuations in plasma drug concentration and cannot render sustained effect.1 However, the TDDS can meet the requirement to keep relatively stable plasma drug concentration and prolong delivery of drug, in a steady-state profile and minimizes the peak-associated side effects, which thus ensures the level of the drug is effective for treatment on the minimal therapeutic concentration. In general, Transdermal drug delivery system, as a controlled drug delivery system, is exceedingly humanized, commodious and prolong the period of time of release of drug, if need arises (e.g. systemic toxicity) with less pain sensation while administrating drug candidates. Additionally, TDDS permits the permeation of drugs across the skin and into the systemic circulation which avoids the hepatic first-pass effect observed in the course of oral administration and inconvenience of frequent parenteral administration. As a new drug carrier of TDDS, Microsponges are mostly used for topical 4-10 and oral administration. 11-15 For other topical delivery systems, the traditional delivery systems are required of frequent dosing to keep relatively stable local concentrations of effective constituent for therapeutic effectiveness because of low effectiveness.Thus to avoid this defect it is indispensable to design a new drug delivery system to prolong the residual time of drug in the epidermis or the dermis, while reduce its penetration into the body. For this reason, as a porous polymeric microsphere, Microsponges can fulfill such aims uniquely.4 Microsponges are porous, polymeric microspheres (Figure 1) which are invariably used for topical delivery system; 4-5,7-10 its inside are full of lacunas and its particle size is 5~300μm in diameter. AbstractTransdermal drug delivery system (TDDS) is a dosage form designed to deliver drug through skin by topical route of administration to the systemic circulation or for local treatment. As a new type of dosage form, TDDS has a number of special merits, but inevitably at the same time it possess some distinct disadvantages, such as low permeability and the drug mostly enter the systemic vascular. Microsponges are a kind of micro-sized and polyporous particles which can entrap effective constituents, and are biologically safe. And Microsponges also exhibit distinctive advantage at the aspect of drug release. The TDDS can enhance drug stability, decrease side effec...

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“…A typical microsponge bead is a 25 mm-sized sphere which can have up to 250,000 pores and an average internal pore structure equivalent to 10 ft in length with an average pore volume of about 1 mL/gm. The surface can be varied from 20 to 500 m 2 /gm and the pore volume range from 0.1 to 0.3 cc/gm [2,3]. Microsponges, which are porous and polymeric microspheres, were mainly used for topical use [3,4], but recently the oral administration was also proposed [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of carvedilol-loaded microsponges with nanometric pores using response surface methodology

Saini

Singh

Verma

2012

Journal of Experimental Nanoscience

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This study demonstrates the use of factorial design for the preparation of microsponges of carvedilol with nanometric pores using the response surface methodology and to establish the functional relationships between two operating variables of Eudragit RS100 and sucrose. The response variables selected for this study were percent drug entrapment (Y1), time taken to release 35% of drug (Y2), percent drug release after 24 h (Y3), percent dissolution efficiency (DE) (Y4) and the angle of repose (Y5). The overall calculated desirability was found to be 0.8065 for the optimised formulation OF1. The response surface analysis of the desirability function with the independent levels indicated that the overall desirability increases with high levels of Eudragit RS100 and sucrose content. The optimum robust formulation (OF1) contains high levels of Eudragit RS100 (400.0 mg) and sucrose (350.21 mg), satisfying the predetermined constraints and goals of all the selected response variables. The scanning electron microscopy of OF1 indicated the spherical shape of microsponges with numerous pores on the surface. The atomic force microscopic study suggested the presence of nanometric pores on the surface of microsponges which may facilitate the release of the drug. Compatibility studies using the Fourier transform infrared spectroscopy, X-ray diffraction and differential scanning calorimeter indicated the absence of any incompatibility between carvedilol and excipients used to prepare microsponges.

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The Microsponge® Delivery System (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives

Cited by 144 publications

References 4 publications

Advanced Trends in Treatment of Wounds

Advanced Trends in Treatment of Wounds

Toward Application of Microsponges in Transdermal Drug Delivery System

Evaluation of carvedilol-loaded microsponges with nanometric pores using response surface methodology

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