The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology

Volpicelli, Floriana; Speranza, Luisa; Pulcrano, Salvatore; Gregorio, Roberto De; Crispino, Marianna; Sanctis, Claudia De; Leopoldo, Marcello; Lacivita, Enza; Porzio, Umberto di; Bellenchi, Gian Carlo; Perrone-Capano, Carla

doi:10.1007/s12035-019-01690-x

Cited by 26 publications

(19 citation statements)

References 65 publications

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“…Altogether, the reported findings on the 5-HT7R signaling in the brain, gut and immune system, suggest the involvement of this receptor in the pathways underlying bidirectional communication between gut and brain possibly with the immune system as a mediator among them. For instance, as mentioned above, two very recent studies showed that 5-HT7R is a direct target of miR-29a in brain, as well as in the intestine [33,34], suggesting that this miRNA might coordinately modulate 5-HT7R expression in both tissues.…”

Section: The 5-ht7r In the Gut And In The Immune Systemmentioning

confidence: 83%

“…Recently, several lines of investigation on this receptor have deepened the knowledge on its crucial role in a wide range of physiological functions, both in the mammalian CNS and in peripheral organs. For instance, recently two independent research groups demonstrated that the microRNA (miR)-29a is able to modulate 5-HT7R expression in the brain, as well as in the gut [33,34]. In the mammalian CNS, the 5-HT7R is mainly expressed in spinal cord, thalamus, hypothalamus, hippocampus, prefrontal cortex, striatal complex, amygdala and in the Purkinje neurons of the cerebellum [35,36].…”

Section: The 5-ht7rmentioning

confidence: 99%

“…It has been recently hypothesized that this decline could be due to the simultaneous upregulation of the miR-29a in the developing hippocampus. Indeed 5-HT7R mRNA is downregulated by the miR-29a in cultured hippocampal neurons and miR-29a overexpression impairs the 5-HT7R-dependent neurite elongation [33]. Neuronal remodeling is highly influenced by the extracellular matrix.…”

Section: Role Of the 5-ht7r In Shaping Neuronal Circuits During Develmentioning

confidence: 99%

See 2 more Smart Citations

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2019

Preprint

Self Cite

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Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology considerably advanced in the last few years. A wealth of data show that the 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows to rescue long term potentiation (LTP) and long term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, possibly playing a role in the gut-brain axis, and modulates the function of immune cells. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gut and immune system.

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Section: The 5-ht7r In the Gut And In The Immune Systemmentioning

confidence: 83%

Section: The 5-ht7rmentioning

confidence: 99%

Section: Role Of the 5-ht7r In Shaping Neuronal Circuits During Develmentioning

confidence: 99%

See 1 more Smart Citation

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2019

Preprint

Self Cite

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show abstract

“…Altogether, the reported findings on the 5-HT7R signaling in the CNS, GI tract and immune system suggest the involvement of this receptor in inflammatory and immune-mediated disorders affecting the gut and brain (Figure 2). For instance, as mentioned above, two very recent studies showed that 5-HT7R is a direct target of miR-29a in the brain, as well as in the intestine [63,111], suggesting that this miRNA might modulate 5-HT7R expression in both tissues in a coordinated way.…”

Section: The 5-ht7r In the Gut And In The Immune Systemmentioning

confidence: 83%

“…It has been recently hypothesized that this decline could be due to the simultaneous upregulation of the microRNA (miR)-29a in the developing hippocampus. Indeed 5-HT7R mRNA is downregulated by the miR-29a in cultured hippocampal neurons, and miR-29a overexpression impairs the 5-HT7R-dependent neurite elongation [63].…”

Section: Role Of the 5-ht7r In Shaping Neuronal Circuits During Develmentioning

confidence: 98%

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2020

IJMS

Self Cite

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Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.

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Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth

Jiang

Han

et al. 2022

Cell. Mol. Life Sci.

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The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology

Cited by 26 publications

References 65 publications

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth

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