2013
DOI: 10.1186/1476-4598-12-43
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Abstract: MicroRNAs(miRNA) are noncoding RNAs of about 19–23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family … Show more

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Cited by 141 publications
(133 citation statements)
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“…Deregulated miR-148a expression can be detected in many tumors, for example from lung, stomach, prostate, brain, and pancreas, potentially affecting survival, proliferation, and cell migration by influencing the abundance of apoptotic proteins, transcription factors (such as Mitf and Runx3), and the feedback regulatory miR-148a/DNMT1 axis [38][39][40].…”
Section: Discussionmentioning
confidence: 99%
“…Deregulated miR-148a expression can be detected in many tumors, for example from lung, stomach, prostate, brain, and pancreas, potentially affecting survival, proliferation, and cell migration by influencing the abundance of apoptotic proteins, transcription factors (such as Mitf and Runx3), and the feedback regulatory miR-148a/DNMT1 axis [38][39][40].…”
Section: Discussionmentioning
confidence: 99%
“…as reviewed. 19 These point to the fact that they may act as tumor suppressor in MM as well. As known, microRNAs are regulated at transcriptional level and at post-transcriptional level, 38 and mature miRNA has 2 arms, the 5p and 3p.…”
Section: Discussionmentioning
confidence: 99%
“…19 In our study, we assessed 4 miRNAs (miR-152, 15a, 34, and 223) in MM and non-MM groups. Our results suggested that miR-152 expression was significantly downregulated in the majority of MM patients and cell lines compared with non-MM; consistent with the reports from other cancers.…”
Section: Discussionmentioning
confidence: 99%
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“…Indeed, a number of these miRNAs were recognized to promote cell proliferation and regulate apoptosis and were linked to the regulation of immune cell activation (e.g., miR-148/152 family, miR-132/212, miR-19 superfamily, and miR-7 family). Among these miRNAs, the miR-148/ 152 family (e.g., miR-148a, miR-148b, and miR-152) is involved in the regulation of cell proliferation, differentiation, and growth, as well as immune responses by suppressing the expression of proinflammatory molecules (e.g., IL-12, IL-6, TNF-a, and IFN-b) (25,26). miR-132/212 belongs to a gene cluster whose expression is regulated by CREB, a transcription factor that provides survival signals for many cells, including macrophages (21).…”
mentioning
confidence: 99%