The microbiota–gut–brain interaction in regulating host metabolic adaptation to cold in male Brandt’s voles (<i>Lasiopodomys brandtii</i>)

Bo, Tingbei; Zhang, Xueying; Wen, Jing; Deng, Ke; Qin, Xiaowei; Wang, Dehua

doi:10.1038/s41396-019-0492-y

Cited by 77 publications

(59 citation statements)

References 67 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mothur was used to construct rarefaction curves of ASV richness vs. sequencing depth (Figure S1) and Good’s coverage values averaged 97.78 ± 0.91 across all samples, indicating that sample coverage was high and appropriate for characterizing fecal microbiota profiles. These values are comparable to those typically reported for other mammalian gut microbiota studies [21, 22, 87].…”

Section: Methodssupporting

confidence: 90%

Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales

Rojas

Ramírez‐Barahona

Holekamp

et al. 2020

Preprint

View full text Add to dashboard Cite

The gut microbiota is critical for host function. Among mammals, host phylogenetic relatedness and diet are strong drivers of gut microbiota structure, but one factor may be more influential than the other. Here, we used 16S rRNA gene sequencing to determine the relative contributions of host phylogeny and host dietary guild in structuring the gut microbiotas of 11 herbivore species from 5 families living sympatrically in southwest Kenya. Herbivore species were classified as grazers, browsers, or mixed-feeders. We found that gut microbiotas were highly species-specific, and that host family accounted for more variation in the gut microbiota (35%) than did host dietary guild (14%). Overall, similarity among gut microbiotas increased with host phylogenetic relatedness (r=0.73), yet this relationship was not apparent among seven closely related Bovid host species (r=0.21 NS). In bovids, host dietary guild explained twice as much variation in the gut microbiota as did host species. Lastly, we found that the gut microbiotas of herbivores residing in southwest Kenya closely resemble those of conspecifics from central Kenya, suggesting that regardless of variability in host local habitat, hosts consistently provide microbes with similar niches for colonization. Overall, our findings suggest that host phylogeny may structure the gut microbiota at broad taxonomic scales, but that host ecology may be more influential in shaping the gut microbiotas of closely related host species.

show abstract

Section: Methodssupporting

confidence: 90%

Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales

Rojas

Ramírez‐Barahona

Holekamp

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…They generated more heat from feeding and the body to maintain a constant body temperature. As has been described in previous studies, the ADG of sheep decreased signi cantly under wind treatment and became negative [22].…”

Section: Discussionsupporting

confidence: 78%

“…When the sheep were exposed to cold temperature, DMIdecreased sharply. In contrast, Bo reported that voles exposed to cold temperature (4°C) increased their food intake [22] to maintain a constant body temperature. However, in the present study, the range of temperature was very large.…”

Section: Discussionmentioning

confidence: 91%

Effects of Low Temperature and Wind Treatment on Physiological Indexes, Rumen Microbiota, Immune Responses and Hormones in Sheep

Guo¹,

Zhou²,

Tian³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Low-temperature environments can strongly affect the normal growth and health of livestock. Previous studies have shown that cold exposure can alter the intestinal microbiota and thereby affect other traits. In winter, cold weather can be accompanied by strong winds that aggravate the effects of cold on livestock. In this study, an experiment was conducted to investigate the effect of low temperature and wind speed on physiological indexes, rumen microbiota, and immune responses in sheep.Methods: The sheep were divided into control group and test group according to their ambient temperature.Sheep in the test group were divided into four groups according to wind-speed treatment: no wind (average wind velocity less than 0.5 m/s), low wind velocity (average wind velocity of 3 m/s), medium wind velocity (average wind velocity of 4 m/s) and high wind velocity (average wind velocity of 5 m/s).Results: Average daily gain and the utilization of forage, especially soluble fiber, decreased with increasing wind velocity in cold temperature (P<0.05). In rumen, the enzyme activity of cellulose degradation was also lowerwith increasing wind velocity (P<0.05). The abundance of potentially beneficial bacteria showed differedamong the wind treatments (P<0.05).The large fluctuations in the amount of bacteria provided a breeding opportunity forpotentially harmful bacteria (P<0.05). In addition, there were significant decreases in the serum levels of IL-2 and IFN-γ (P<0.05) and a large increase in IL-4 level (P<0.05), which indicated that the sheep underwent immune suppressionduring the trial. The significant increase in the activities of the antioxidant enzymes SOD, GSH-PX, and CAT (P<0.05) indicated that the production of oxygen free radicals was increased.Conclusions: The cold environment significantly reduced the growth of sheep and altered the composition of rumen microbiota, reducing the utilization of soluble fiber by the rumen flora. Furthermore, the sheep produced large amounts of enzymes to resist tissue damage and experienced immune suppression in the cold environment.

show abstract

“…However, the effects of increased or decreased T a on gut microbial community structure were reported mainly in invertebrates or ectotherms ( 17 , 18 ). Only a few studies have reported cold-induced variation in gut microbial communities in laboratory mice and Brandt’s voles ( Lasiopodomys brandtii ) ( 19 – 21 ). There are no data on the response of gut microbiota and their relationship with metabolic plasticity in mammal species exposed to frequent high or low T a in the context of global climate change.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

et al. 2020

Self Cite

View full text Add to dashboard Cite

Ambient temperature (Ta) is an important factor in shaping phenotypic plasticity. Plasticity is generally beneficial for animals in adapting to their environments. Gut microbiota are crucial in regulating host physiological and behavioral processes. However, whether the gut microbiota play a role in regulating host phenotypic plasticity under the conditions of repeated fluctuations in environmental factors has rarely been examined. We used intermittent Ta acclimations to test the hypothesis that the plasticity of gut microbiota confers on the host a metabolic adaptation to Ta fluctuations. Mongolian gerbils (Meriones unguiculatus) were acclimated to intermittent 5°C to 23°C, 37°C to 23°C or 23°C to 23°C conditions for 3 cycles (totally 3 months). Intermittent Ta acclimations induced variations in resting metabolic rate (RMR), serum thyroid hormones, and core body temperature (Tb). We further identified that the β-diversity of the microbial community varied with Ta and showed diverse responses during the 3 cycles. Some specific bacteria were more sensitive to Ta and were associated with host dynamic metabolic plasticity during Ta acclimations. In addition, depletion of gut microbiota in antibiotic-treated gerbils impaired metabolic plasticity, particularly at low Ta, whereas supplementation with propionate as an energy resource improved the inhibited thermogenic capacity and increased the survival rate in the cold. These findings demonstrate that both gut microbiota and their host were more adaptive after repeated acclimations, and dynamic gut microbiota and their metabolites may confer host plasticity in thermoregulation in response to Ta fluctuations. It also implies that low Ta is a crucial cue in driving symbiosis between mammals and their gut microbiota during evolution. IMPORTANCE Whether gut microbiota play a role in regulating host phenotypic plasticity in small mammals living in seasonal environments has rarely been examined. The present study, through an intermittent temperature acclimation model, indicates that both gut microbiota and their host were more adaptive after repeated acclimations. It also demonstrates that dynamic gut microbiota confer host plasticity in thermoregulation in response to intermittent temperature fluctuations. Furthermore, low temperature seems to be a crucial cue in driving the symbiosis between mammals and their gut microbiota during evolution.

show abstract

The microbiota–gut–brain interaction in regulating host metabolic adaptation to cold in male Brandt’s voles (Lasiopodomys brandtii)

Cited by 77 publications

References 67 publications

Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales

Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales

Effects of Low Temperature and Wind Treatment on Physiological Indexes, Rumen Microbiota, Immune Responses and Hormones in Sheep

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

Contact Info

Product

Resources

About