The microbiota and gut-brain axis

Kraus, Melina; Çetin, Mesut; Arýcioðlu, Feyza

doi:10.5455/jmood.20161004082122

Cited by 3 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, intestinal bacteria play key roles in behaviour [ 8 ], immune function [ 9 ], nutrient absorption [ 10 , 11 ], storage of fats [ 12 ], and detoxification of ingested metals and other pollutants [ 13 , 14 ]. A high diversity of intestinal microbiota is essential to maintaining the assemblage’s resilience to environmental changes [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Wastewater treatment works change the intestinal microbiomes of insectivorous bats

et al. 2021

View full text Add to dashboard Cite

Mammals, born with a near-sterile intestinal tract, are inoculated with their mothers’ microbiome during birth. Thereafter, extrinsic and intrinsic factors shape their intestinal microbe assemblage. Wastewater treatment works (WWTW), sites synonymous with pollutants and pathogens, receive influent from domestic, agricultural and industrial sources. The high nutrient content of wastewater supports abundant populations of chironomid midges (Diptera), which transfer these toxicants and potential pathogens to their predators, such as the banana bat Neoromicia nana (Vespertilionidae), thereby influencing their intestinal microbial assemblages. We used next generation sequencing and 16S rRNA gene profiling to identify and compare intestinal bacteria of N. nana at two reference sites and two WWTW sites. We describe the shared intestinal microbiome of the insectivorous bat, N. nana, consisting of seven phyla and eleven classes. Further, multivariate analyses revealed that location was the most significant driver (sex, body size and condition were not significant) of intestinal microbiome diversity. Bats at WWTW sites exhibited greater intestinal microbiota diversity than those at reference sites, likely due to wastewater exposure, stress and/or altered diet. Changes in their intestinal microbiota assemblages may allow these bats to cope with concomitant stressors.

show abstract

Section: Introductionmentioning

confidence: 99%

Wastewater treatment works change the intestinal microbiomes of insectivorous bats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Therefore, probiotics will have great potential as a new target for the treatment of neuropsychiatric disorders. There is a study reporting that the anxiety state was improved significantly in patients administered with the strain of Lactic acid bacteria as compared with those in the placebo group (9), which also further supports the use of the gut microbiota as a target of viable treatment.…”

Section: Probiotics and Prebiotics As A Target Will Be A New Treatment For Neuropsychiatric Diseases What Can We Do?mentioning

confidence: 64%

“…In recent years, the human gut microbiota, particularly beneficial gut microbiota, probiotics and prebiotics, has become a hot spot of research and progressing rapidly. Probiotics can stabilize anxiety-like and depressive-like behavior through the MGB axis (8,9). It is reported that eating an appropriate number of probiotic-based products can help regulate inflammatory diseases and is beneficial to patients with irritable bowel syndrome (IBS) antibiotic-associated diarrhea or pouchitis.…”

Section: Review Articlementioning

confidence: 99%

A narrative review of relationship between gut microbiota and neuropsychiatric disorders: mechanisms and clinical application of probiotics and prebiotics

Yang¹,

Liu²,

Cai³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

The gut microbiota is a kind of fixed-value bacteria in the human intestine, characterized by a large quantity, a wide variety and interdependence with each other and with the host. The gut microbiota is considered to be an important link in maintaining health and pathogenic mechanism of many diseases.The gut microbiota affects the central nervous system under the action of the microbe-gut-brain axis through nerve, immune, endocrine and metabolic pathways. The gut microbiota not only regulates the gastrointestinal tract but plays a vital role in the development and function of the brain. More and more studies believe that normal gut microbiota is essential for the development of the central nervous system and emotional regulation. The imbalance of the gut microbiota can affect some neuropsychiatric diseases.Probiotics and prebiotics are active microorganisms beneficial to the human body and can regulate the microecological balance of the human intestinal tract. Current research shows that probiotics and prebiotics have a good preventive effect on Alzheimer's disease, Parkinson's disease, depression, autism spectrum disorders and other neurological and mental diseases. Based on this, we review the relevant research on the pathogenesis of probiotics and prebiotics and neuropsychiatric diseases, in an attempt to providing new ideas for exploring the treatment and prevention of neuropsychiatric diseases.

show abstract

“…They also have been shown to improve quality of life in children with cystic fibrosis (Jafari et al, 2013). Furthermore, recent research has suggested in addition to the functional properties of the human microbiota, the latter also plays a role in brain development and can be linked to autism, depression, anxiety and stress (Abildgaard, Elfving, Hokland, Wegener, & Lund, 2017;Kraus, Cetin, & Aricioglu, 2016;Nduti et al, 2016;Sawada et al, 2017;Severance et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Study on the functional properties of potential indigenous probiotics isolated from human samples in West Africa

Fredua‐Agyeman

Ofosu-Boateng

Offei

et al. 2020

LWT

View full text Add to dashboard Cite

A study was performed to identify and characterize 99 indigenous strains isolated from human breast milk (n=29) and fecal samples (n=70) in Ghana, using methods ranging from plating growth tests, conforming to (NCCLS) standards and presumptive analysis at species level using MALDI-TOF MS, prior to validation through qPCR techniques. Antimicrobial activities of the isolated strains were performed by the agar well diffusion assay. Gastrointestinal tolerance and ability to grow biofilms in vitro using 3D Alvatex platform were determined. Results indicate that out of 99 samples, 25 were gram-positive, catalase-negative rods, 80% of which were Lactobacillus strains. More than one-third of the identified strains were L. fermentum followed by L. plantarum, L. rhamnosus, L. salivarius, L. reuteri along with Enterococcus faecium, Weissella spp. and Pediococcus spp. Among the 25 isolates, 9 had activity against both gram-negative and gram-positive tested pathogens including Staphylococcus aureus, Escherichia coli ATCC 25922, E. coli BAA-2471, Salmonella typhi, and Pseudomonas aeruginosa. The indigenous microbiota proved to be most effective antimicrobial to local pathogens over nonindigenous pathogens. The data also showed maintained cell viability for all studied isolate at pH 2, 3 and 6 followed by a successful growth of the co-cultured biofilm in a 3D Alvatex platform.

show abstract

The microbiota and gut-brain axis

Cited by 3 publications

References 16 publications

Wastewater treatment works change the intestinal microbiomes of insectivorous bats

Wastewater treatment works change the intestinal microbiomes of insectivorous bats

A narrative review of relationship between gut microbiota and neuropsychiatric disorders: mechanisms and clinical application of probiotics and prebiotics

Study on the functional properties of potential indigenous probiotics isolated from human samples in West Africa

Contact Info

Product

Resources

About