The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices

Fuentes-Chust, Celia; Parolo, Claudio; Rosati, Giulio; Rivas, Lourdes; Perez‐Toralla, Karla; Simon, Stéphanie; Lecuona, Itziar de; Junot, Christophe; Trebicka, Jonel; Merkoçi, Arben

doi:10.1002/adma.202006104

Cited by 27 publications

(17 citation statements)

References 137 publications

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“…The role of nanotechnology in this endeavor cannot be overlooked as it provides a wide range of possibilities (Fuentes-Chust et al, 2021) for probing bacteria-cancer relationship. For instance, aptamer conjugated nanomaterials evolved from cell-SELEX, can be used for cancer and pathogenic bacterial detection (Gedi & Kim, 2014).…”

Section: Discussionmentioning

confidence: 99%

Bacterial infections in cancer: A bilateral relationship

Basu

Singh

Gupta

2022

WIREs Nanomed Nanobiotechnol

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Bacteria share a long commensal relationship with the human body. New findings, however, continue to unravel many complexities associated with this old alliance. In the past decades, the dysbiosis of human microbiome has been linked to tumorigenesis, and more recently to spontaneous colonization of existing tumors. The topic, however, remains open for debate as the claims for causative-prevailing dual characteristics of bacteria are mostly based on epidemiological evidence rather than robust mechanistic models. There are also no reviews linking the collective impact of bacteria in tumor microenvironments to the efficacy of cancer drugs, mechanisms of pathogen-initiated cancer and bacterial colonization, personalized nanomedicine, nanotechnology, and antimicrobial resistance. In this review, we provide a holistic overview of the bilateral relationship between cancer and bacteria covering all these aspects. Our collated evidence from the literature does not merely categorize bacteria as cancer causative or prevailing agents, but also critically highlights the gaps in the literature where more detailed studies may be required to reach such a conclusion. Arguments are made in favor of dual drug therapies that can simultaneously co-target bacteria and cancer cells to overcome drug resistance. Also discussed are the opportunities for leveraging the natural colonization and remission power of bacteria for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Bacterial infections in cancer: A bilateral relationship

Basu

Singh

Gupta

2022

WIREs Nanomed Nanobiotechnol

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“…In the past decade, the inclusion of nanomaterials led to better performance with lower LOD and other benefits. − Nanomaterials (those of 100 nm size or smaller) have properties that diverge from those of the same materials at the macroscopic scale, presenting phenomena such as electromagnetic field enhancement, quantum confinement, and plasmonic resonance, which can be exploited for signal amplification . There are recent reviews devoted to nanomaterials and their promising applications in LF, which are too wide to be included in this review.…”

Section: Lateral Flowmentioning

confidence: 99%

Toward Integrated Molecular Lateral Flow Diagnostic Tests Using Advanced Micro- and Nanotechnology

2022

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“…Therefore, glucose analogues that cannot be degraded by the cells are used for targeting the tumor microenvironment, thereby distinguishing the tumor from normal tissues at the metabolic level. To date, a great deal of research has improved diagnostic efficiency and specificity in the intestine by combining these small-molecule substances with nanotechnology and engineered bacteria [130,131].…”

Section: Construction Of a Bioimaging Systemmentioning

confidence: 99%

Developing sensor materials for screening intestinal diseases

Zhao¹,

Zhang²,

Chen³

et al. 2022

Mater. Futures

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Intestinal diseases have always been the focus of clinicians and scientific researchers, which have high mortality and morbidity rates, and bring huge encumbrance on the public medical system and economy worldwide. In the progression of many intestinal diseases, early diagnosis and intervention are valuable. Fortunately, the emergence of sensor materials can effectively assist clinical early diagnosis and health monitoring. By accurately locating the lesion and sensitively analyzing the level of disease markers, these sensor materials can help to precisely diagnose the stage and state of lesions, thereby avoiding delaying the treatment. In this review, we provide a comprehensive and in-depth knowledge into diagnosing and monitoring intestinal diseases with the assistance of sensor materials, particularly emphasizing the design and application of them in bioimaging and biodetection. This review is dedicated to conveying the practical applications of sensor materials in the intestine, a critical analysis of their mechanisms and applications, and discussion of their future roles in medicine. We believe that this review would promote the multidisciplinary communication between material science, medicine, and the relevant engineering fields, thus improving the clinical translation of sensor materials

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The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices

Cited by 27 publications

References 137 publications

Bacterial infections in cancer: A bilateral relationship

Bacterial infections in cancer: A bilateral relationship

Toward Integrated Molecular Lateral Flow Diagnostic Tests Using Advanced Micro- and Nanotechnology

Developing sensor materials for screening intestinal diseases

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