Developing sensor materials for screening intestinal diseases

Abstract

Intestinal diseases have always been the focus of clinicians and scientific researchers, which have high mortality and morbidity rates, and bring huge encumbrance on the public medical system and economy worldwide. In the progression of many intestinal diseases, early diagnosis and intervention are valuable. Fortunately, the emergence of sensor materials can effectively assist clinical early diagnosis and health monitoring. By accurately locating the lesion and sensitively analyzing the level of disease markers, these sensor materials can help to precisely diagnose the stage and state of lesions, thereby avoiding delaying the treatment. In this review, we provide a comprehensive and in-depth knowledge into diagnosing and monitoring intestinal diseases with the assistance of sensor materials, particularly emphasizing the design and application of them in bioimaging and biodetection. This review is dedicated to conveying the practical applications of sensor materials in the intestine, a critical analysis of their mechanisms and applications, and discussion of their future roles in medicine. We believe that this review would promote the multidisciplinary communication between material science, medicine, and the relevant engineering fields, thus improving the clinical translation of sensor materials

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“…)‐based sensor devices have been widely reported in the field of biomolecule detection. [ 31 ] Compared to other 2D materials, monolayer graphene exhibits minimal hindrance to electronic transport due to its lattice structure, resulting in a ultra‐high carrier mobility of up to 2 × 10 5 cm 2 V −1 s −1 . [ 32 ] This characteristic indicates that graphene‐based sensor devices have ultra‐high sensitivity when detecting charged biomolecules.…”

Engineering multifunctional adhesive hydrogel patches for biomedical applications

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Modulating piezoelectricity and mechanical strength via three-dimensional gradient structure for piezoelectric composites

“…Dielectric materials with unique electric-coupling properties such as dielectricity, piezoelectricity, ferroelectricity and pyroelectricity have been extensively applied in electronic devices, 1 energy storage devices, 2 medical equipment 3 and military weapons. 4 The piezoelectricity of dielectric materials can convert mechanical energy into electricity, which is critical for flexible electronics 5–9 and energy harvesting. 10 Typical piezoelectric ceramics exhibit an outstanding piezoelectric response, but unfortunately, the inherent brittleness and rigidness limit their applications.…”