The Microbiome in Osteoarthritis: a Narrative Review of Recent Human and Animal Model Literature

Dunn, Christopher M.; Jeffries, Matlock A.

doi:10.1007/s11926-022-01066-6

Cited by 15 publications

(22 citation statements)

References 68 publications

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“…In humans, Clostridiales and the genus Streptococcus were associated with OA pain [ 4 ], and nutrient metabolism influenced functional changes in the gut microbiome in OA [ 5 ]. Our pre-clinical data showing that LA restores gut microbial balance and improves OA pain and joint pathology can be applied to human subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Recent human and mouse studies have demonstrated changes in gut microbiome in OA [ 4 ]. Reduced alpha diversity and altered functional composition of the gut microbiome is suggested to occur in OA.…”

Section: Introductionmentioning

confidence: 99%

“…Reduced alpha diversity and altered functional composition of the gut microbiome is suggested to occur in OA. In human subjects, the order Clostridiales correlates negatively with OA and genus Streptococcus associates with OA pain [ 4 ]. Metabolomic studies on fecal samples from human OA subjects have revealed associations of leukotriene and amino acid metabolism, glycosylphosphatidylinositol anchor biosynthesis, and pyruvate metabolism with OA reflecting functional changes in the gut microbiome in OA [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Depletion of the gut microbiome in gnotobiotic or antibiotic treated mice has been shown to alleviate OA in different animal models of the disease [ 4 , 6 , 7 ]. Furthermore, germ-free mice colonized with the fecal microbiome of human OA subjects exhibit higher OA severity in a surgical OA model [ 4 , 8 ]. These data suggest that gut microbial communities contribute to the pathology of OA.…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus acidophilus Mitigates Osteoarthritis-Associated Pain, Cartilage Disintegration and Gut Microbiota Dysbiosis in an Experimental Murine OA Model

et al. 2022

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To test probiotic therapy for osteoarthritis (OA), we administered Lactobacillus acidophilus (LA) by oral gavage (2×/week) after induction of OA by partial medial meniscectomy (PMM). Pain was assessed by von Frey filament and hot plate testing. Joint pathology and pain markers were comprehensively analyzed in knee joints, spinal cords, dorsal root ganglia and distal colon by Safranin O/fast green staining, immunofluorescence microscopy and RT-qPCR. LA acutely reduced inflammatory knee joint pain and prevented further OA progression. The therapeutic efficacy of LA was supported by a significant reduction of cartilage-degrading enzymes, pain markers and inflammatory factors in the tissues we examined. This finding suggests a likely clinical effect of LA on OA. The effect of LA treatment on the fecal microbiome was assessed by 16S rRNA gene amplicon sequencing analysis. LA significantly altered the fecal microbiota compared to vehicle-treated mice (PERMANOVA p < 0.009). Our pre-clinical OA animal model revealed significant OA disease modifying effects of LA as reflected by rapid joint pain reduction, cartilage protection, and reversal of dysbiosis. Our findings suggest that LA treatment has beneficial systemic effects that can potentially be developed as a safe OA disease-modifying drug (OADMD).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lactobacillus acidophilus Mitigates Osteoarthritis-Associated Pain, Cartilage Disintegration and Gut Microbiota Dysbiosis in an Experimental Murine OA Model

et al. 2022

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“…On this basis, Gleason et al ( 34 ) emphasized the role of gut-joint axis in the pathogenic process of OA, and recognized that the gut-joint axis was proposed as an association involving the gastrointestinal microbiome, immune and inflammatory response that it induced, and the overall joint health. Meanwhile, the gut is regarded as an intriguing and novel target for the therapy of OA, and the dietary modification or supplementation with fiber, probiotics, or prebiotics could provide a positive influence on the gut-joint axis ( 35 , 36 ).…”

Section: The Close Correlation Between Osteoarthritis Obesity and Gut...mentioning

confidence: 99%

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

Liu

Tian

et al. 2022

Front. Nutr.

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Osteoarthritis (OA) is a common chronic degenerative disease of articular cartilage in middle-aged and older individuals, which can result in the joint pain and dysfunction, and even cause the joint deformity or disability. With the enhancing process of global aging, OA has gradually become a major public health problem worldwide. Explaining pathogenesis of OA is critical for the development of new preventive and therapeutic interventions. In recent years, gut microbiota (GM) has been generally regarded as a “multifunctional organ,” which is closely relevant with a variety of immune, metabolic and inflammatory functions. Meanwhile, more and more human and animal researches have indicated the existence of gut-bone axis and suggested that GM and its metabolites are closely involved in the pathogenic process of OA, which might become a potential and promising intervention target. Based on the close coordination of gut-bone axis, this review aims to summarize and discuss the mechanisms of GM and its metabolites influencing OA from the aspects of the intestinal mucosal barrier modulation, intestinal metabolites modulation, immune modulation and strategies for the prevention or treatment of OA based on perspectives of GM and its metabolites, thus providing a profound knowledge and recognition of it.

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Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Song,

Liu,

Chen

et al. 2024

Anim Models and Exp Med

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BackgroundKnee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research. Chinese herbal compounds, which consist of multiple herbs with diverse pharmacological properties, possess characteristics such as multicomponent, multipathway, and multitarget effects. The potential benefits in the treatment of KOA continue to attract attention.PurposeThis study aims to provide a comprehensive overview of the advantages, limitations, and specific considerations in selecting different species and methods for KOA animal models. This will help researchers make informed decisions when choosing an animal model.MethodsOnline academic databases (e.g., PubMed, Google Scholar, Web of Science, and CNKI) were searched using the search terms “knee osteoarthritis,” “animal models,” “traditional Chinese medicine,” and their combinations, primarily including KOA studies published from 2010 to 2023.ResultsBased on literature retrieval, this review provides a comprehensive overview of the methods of establishing KOA animal models; introduces the current status of advantages and disadvantages of various animal models, including mice, rats, rabbits, dogs, and sheep/goats; and presents the current status of methods used to establish KOA animal models.ConclusionThis study provides a review of the animal models used in recent KOA research, discusses the common modeling methods, and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

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The Microbiome in Osteoarthritis: a Narrative Review of Recent Human and Animal Model Literature

Cited by 15 publications

References 68 publications

Lactobacillus acidophilus Mitigates Osteoarthritis-Associated Pain, Cartilage Disintegration and Gut Microbiota Dysbiosis in an Experimental Murine OA Model

Lactobacillus acidophilus Mitigates Osteoarthritis-Associated Pain, Cartilage Disintegration and Gut Microbiota Dysbiosis in an Experimental Murine OA Model

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

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