The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection

Koh, Andrew Y.

doi:10.1371/journal.ppat.1006342

Cited by 14 publications

(12 citation statements)

References 24 publications

(38 reference statements)

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“…Compromised barrier allows microorganisms or bacterial products to enter the blood circulation [10]. Consequently, the immune response in the form of inflammatory cytokines leads to inflammation, bloodstream infections (BSI), i.e.…”

Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

“…Consequently, the immune response in the form of inflammatory cytokines leads to inflammation, bloodstream infections (BSI), i.e. bacteremia and fungemia, GvHD, and sepsis [10]. BSI are predominantly caused by Pseudomonas a eruginosa , Escherichia coli , and Candida albicans [10].…”

Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

“…bacteremia and fungemia, GvHD, and sepsis [10]. BSI are predominantly caused by Pseudomonas a eruginosa , Escherichia coli , and Candida albicans [10]. To prevent BSI in patients receiving al logenic hematopoietic stem cell transplantation (allo-HSCT), very often prophylactic antibiotics are used.…”

Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

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The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials

et al. 2018

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The human gut microbiota gained tremendous importance in the last decade as next-generation technologies of sequencing and multiomics analyses linked the role of the microbial communities to host physiology and pathophysiology. A growing number of human pathologies and diseases are linked to the gut microbiota. One of the main mechanisms by which the microbiota influences the host is through its interactions with the host immune system. These interactions with both innate and adaptive host intestinal and extraintestinal immunity, although usually commensalistic even mutualistic with the host, in some cases lead to serious health effects. In the case of allogenic hematopoietic stem cell transplantation (allo-HSCT), the disruption of the intestinal microbiota diversity is associated with acute graft-versus-host disease (GvHD). Causing inflammation of the liver, skin, lungs, and the intestine, GvHD occurs in 40–50% of patients undergoing allo-HSCT and results in significant posttransplantation mortality. In this review, we highlight the impact of the gut microbiota on the host immunity in GvHD and the potential of microbiota in alleviation or even prevention of GvHD.

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Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

Section: Allogenic Hematopoietic Stem Cell Transplantation and Gvhdmentioning

confidence: 99%

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The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials

et al. 2018

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“…The two classes of medications most frequently given to cancer and stem cell transplant patients are chemotherapeutic agents and antibiotics. This begs the question as to whether these medications contribute to the fact that these patients are at such high risk of developing CA invasive infections originating from the gut [3]. Unfortunately, there are no studies in either animals or humans that have examined the effect of cancer chemotherapeutic agents on the gut mycobiome, so further studies are merited.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…In cancer and stem cell transplant patients, CA colonizes the GI tract with subsequent translocation into extraintestinal organs in the setting of chemotherapy- induced neutropenia and GI mucosal damage[3]. In these patients, the role of the gut as a source for disseminated candidiasis was first suggested by older autopsy studies [4] and a recently substantiated by molecular methods [5].…”

Section: Introductionmentioning

confidence: 99%

Adaptation of Candida albicans During Gastrointestinal Tract Colonization

Mishra

Koh

2018

Curr Clin Micro Rpt

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Purpose of Review Colonization of the gastrointestinal (GI) tract with Candida albicans (CA), the most common human fungal pathogen, is the first step towards the development of invasive infection. Yet the fungal virulence factors and host factors that modulate CA GI colonization are still poorly understood. In this review, we will review emerging evidence of the importance of select CA genetic determinants and CA’s interaction with the host that contribute to its successful adaptation as a pathobiont in the human GI tract. Recent Findings Recent data reveal the importance of 1) CA genetic determinants; 2) host factors; and 3) environmental factors in modulating CA GI colonization in humans. Summary As evidence continues to grow supporting the notion that the GI tract and its resident microbiota are an integral part of the host immune system, it will be critical for studies to interrogate the interaction of CA with the host (including both the host innate and adaptive immune system as well as the endogenous gut microbiota) in order to dissect the mechanisms of CA pathogenesis and thus lay the foundation for novel therapeutic approaches to prevent and/or treat invasive fungal infections.

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Foreword

Pizzo

2021

Pediatric Transplant and Oncology Infectious Diseases

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The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection

Cited by 14 publications

References 24 publications

The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials

The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials

Adaptation of Candida albicans During Gastrointestinal Tract Colonization

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