The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Baek, Keumjin; Choi, Youngnim

doi:10.1111/omi.12197

Cited by 54 publications

(56 citation statements)

References 66 publications

(97 reference statements)

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“…Latest researches systematically reviewed the microorganisms might be responsible for OLP, with differences in results from buccal mucosa and saliva specimens [10,12,13,18,19]. In here, we listed our results with those previously reported by Wang et al and other three researchers [12,13,18,19] in Table 6.…”

Section: Discussionmentioning

confidence: 66%

“…Whether oral microbial changes in OLP disease state is not clear, but some studies have confirmed the correlation between OLP and oral microorganism [10]. Bornstein et al [5] investigated microbial in OLP patients with non-erosive/asymptomatic lesions and found that bacterial counts for Capnocytophaga sputigena, Eikenella corrodens, Lactobacillus crispatus, Mobiluncus curtisii, Neisseria mucosa, Prevotella bivia, Prevotella intermedia, and S. agalactiae at the sites of OLP lesions are significantly higher when compared to the same sites in control subjects.…”

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confidence: 99%

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Dysbiosis of saliva microbiome in patients with oral lichen planus

Wang

et al. 2020

BMC Microbiol

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Background: Oral microbiota is not only important for maintaining oral health but also plays a role in various oral diseases. However, studies regarding microbiome changes in oral lichen planus (OLP) are very limited. To the best of our knowledge, there has been only two studies investigating salivary microbiome changes in OLP. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive/ulcerative lesions. Whole saliva samples were collected from 20 patients with OLP (erosive E, n = 10 and non-erosive NE, n = 10), 10 patients with RAU (U) and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing. Results: We obtained 4949 operational taxonomic units (OTUs) from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera Streptococcus and Sphingomonas in saliva from RAU patients when compared to the other three groups. Relative abundance of Lautropia and Gemella were higher in E group, whereas relative abundance of Haemophilus and Neisseria were higher in NE group when compared to C group. Abiotrophia and Oribacterium were higher in OLP (combining E and NE groups), while Eikenella and Aggregatibacter were lower when compared to C group. There was statistically significance in α-diversity between E and RAU groups(p < 0.05). Significant differences in β-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. The LDA effect size algorithm identified the g_Haemophilus might be the potential biomarker in NE group. Conclusions: We found that salivary microbiome in erosive OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.

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Section: Discussionmentioning

confidence: 66%

mentioning

confidence: 99%

Dysbiosis of saliva microbiome in patients with oral lichen planus

Wang

et al. 2020

BMC Microbiol

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“…Latest researches systematically reviewed the microorganisms might be responsible for OLP, with differences in results from buccal mucosa and saliva specimens [10,12,[17][18][19]. In here, we listed our results with those previously reported by Wang et al and other three researchers [12,[17][18][19] in Table 5.…”

Section: Discussionmentioning

confidence: 66%

“…Whether oral microbial changes in OLP disease state is not clear, but some studies have confirmed the correlation between OLP and oral microorganism. [10] Bornstein et al [5] investigated microbial in OLP patients with non-erosive/asymptomatic lesions and found that bacterial counts for Capnocytophaga sputigena, Eikenella corrodens, Lactobacillus crispatus, Mobiluncus curtisii, Neisseria mucosa, Prevotella bivia, Prevotella intermedia, and S. agalactiae at the sites of OLP lesions are significantly higher when compared to the same sites in control subjects. In addition, bacterial counts for Bacteroides ureolyticus, Dialister species, Staphylococcus haemolyticus, and Streptococcus agalactiae were also significantly higher in OLP gingival lesions when compared to those found in the contralateral unaffected sites within the same patient.…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis of saliva microbiome in patients with oral lichen planus

Wang

et al. 2020

Preprint

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Background : Oral microbiota is not only important for maintaining oral health but also plays a role in oral diseases. However, studies regarding microbiome changes in oral lichen planus(OLP)are very limited. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive/ulcerative lesions. Methods : Whole saliva samples were collected from 20 patients with OLP (10 each for erosive (E) and non-erosive (NE) groups), 10 patients with RAU (U group), and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing. Results were assessed with alpha- and beta-diversity, linear discriminant analysis (LDA) effect size, and the data was analyzed by Spearman’s rank correlation,Wilcoxon and Kruskal test. Results: We obtained 4949 operational taxonomic units from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera Streptococcus and Sphingomonas in saliva from RAU patients when compared to the other three groups. Relative abundance of Lautropia and Gemella were higher in E group,whereas relative abundance of Haemophilus and Neisseria were higher in NE group when compared to C group. Abiotrophia and Oribacterium were higher in OLP (combining E and NE groups), while Eikenella and Aggregatibacter were lower when compared to C group. There was statistically significance in α-diversity between E and RAU groups( p <0.05). Significant differences in β-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. Conclusion： We found that salivary microbiome in OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.

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“…Also, different colonization patterns were observed at the sites of oral mucosa affected by lesions compared to healthy control sites within the same patient [53]. However, it has not yet been clarified if the dysbiosis associated with oral lichen planus has some causative role, for example by invading the epithelial barrier and modifying the immune response [54]. Alternatively, the dysbiosis may simply be an epiphenomenon due to the changed oral environment, without having an active role in the immunopathology of oral lichen planus.…”

Section: Oral Lichen Planusmentioning

confidence: 99%

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2019

EDUJ

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You are the new Director of the ERO Working Group-Continuing Medical Education in Dentistry. What are the goals you are considering? Beside Chairing the FDI ERO Working Group-Continuing Medical Education in Dentistry since 2014, I have been appointed as the new FDI Continuing Education Director for Europe right after the FDI 2018 General Assembly in Buenos Aires. Taking over the responsibility of the CE programme directory successfully run by Prof. Dr. Alexandre Mersel, I will support our member NDAs' CE events for them to assume their responsibility to perform their role with respect to the continuing education of the dental profession. Beside supporting our members both by fundamental and clinical practice-based educational activities, I will highlight our motto "Leading the world into optimal oral health" as active representatives of FDI; we need to globally improve sustainable oral health so as to reach our target. And undoubtedly one of these targets is the intent to conduct research into the knowledge about the connection between oral and general health. Therefore besides clinical dental education, we shall be pointing out the vitality of the Continuing Medical Education for the advocacy of global health and raising awareness of the dental profession with respect to the relationship between oral health and general health; one of our program goals is to strongly support improving to way these priorities are addressed by organizing CE events among our NDAs. You attended the FDI Congress in Buenos Aires. How do you assess the quality of the papers presented? What are the topics of interest to oral health specialists? FDI WDC has a broad scope mainly addressing the general practitioners at global level. Aside from the researchbased institution' s congresses, FDI WDC calls clinicians and academics to present their research and cases enabling the publication of the abstracts in the International Dental Journal (IDJ) which is the official peer-reviewed, SCIEindexed journal of FDI. Thus, all abstracts are peer-reviewed and qualified at a required scientific level. Generally, we have submissions under all clinical branches, both scientifically and clinically related abstracts and also prevention and public health-related subjects. However, concerning all the recent submissions most of them are related to clinical cases especially including novel materials and techniques used.

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The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Cited by 54 publications

References 66 publications

Dysbiosis of saliva microbiome in patients with oral lichen planus

Dysbiosis of saliva microbiome in patients with oral lichen planus

Dysbiosis of saliva microbiome in patients with oral lichen planus

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