“…The importance of these ORMDL3-regulated genes to asthma is suggested from studies demonstrating increased expression of many of these mediators in the airways of human asthmatics (MMP-9, ADAM-8, CCL-20, CXCL-10, IL-8) (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), induction of these mediators by allergen inhalation in asthmatics (MMP-9, CCL-20, CXCL-10) (7,12,19), and inhibition of asthma outcomes in mice deficient in these genes (MMP-9, ADAM-8, CXCL-10) (8,9,11,20,21). In addition to the important role of CCL-20 on T-cell recruitment (12), and epithelial mucus production (14), in mouse models of asthma, there is a critical link between CCL-20 and TRAIL for Th2 cell activation and allergic airway inflammation (15).…”