Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12

Paulissen, Geneviève; Hour, Mehdi El; Rocks, Natacha; Guéders, Maud; Bureau, Fabrice; Foidart, Jean-Michel; López-Otı́n, Carlos; Noël, Agnès; Cataldo, Didier

doi:10.4049/jimmunol.1103739

Cited by 27 publications

(30 citation statements)

References 62 publications

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“…In addition, the antiangiogenesis properties of ADAMTS-12 did not rely on the catalytic domain, but, more likely, on its TSP-1 domains [30]. In contrast, the catalytic activity was implicated in the protective effect against allergen-induced inflammation [28]. …”

Section: Structural Organization Of Adamts-12mentioning

confidence: 99%

“…There has been increasing evidence pertaining to the pathological relevance of this enzyme. For instance, ADAMTS-12 has been proven to be associated with the pathogenesis of arthritis [8–16], intervertebral disc degeneration [25, 26], inflammation [27, 28], and invasion and metastasis of tumor [29–31]. Although ADAMTS-7 and -12 share similar structure and domain organization, ADAMTS-7 and -12 may have different pathological effects or be responsible for different phases in a disease [26, 32].…”

Section: Introductionmentioning

confidence: 99%

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ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Wei

Richbourgh

Jia

et al. 2014

Mediators of Inflammation

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ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.

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Section: Structural Organization Of Adamts-12mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Wei

Richbourgh

Jia

et al. 2014

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…For antigen retrieval, the slides were boiled in 10 m M citrate buffer (pH 6.0) for 10 min in a microwave [14]. Digital images were acquired using an Olympus BX50 microscope (Olympus Europa GmbH, Hamburg, Germany) equipped with a Leica 320 digital camera (Leica Microsystems, Wetzlar, Germany).…”

Section: Methodsmentioning

confidence: 99%

Inflammation-Induced Expression of the Alarmin Interleukin 33 Can Be Suppressed by Galacto-Oligosaccharides

Verheijden

Akbari²,

Willemsen³

et al. 2015

Int Arch Allergy Immunol

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Background: The alarmin interleukin 33 (IL-33) and its receptor ST2 play an important role in mucosal barrier tissues, and seem to be crucial for Th2-cell mediated host defense. Galacto-oligosaccharides (GOS), used in infant formulas, exhibit gut and immune modulatory effects. To enhance our understanding of the immunomodulatory capacity of GOS, this study investigated the impact of dietary GOS intervention on IL-33 and ST2 expression related to intestinal barrier dysfunction and asthma. Methods: B6C3F₁ and BALB/c mice were fed a control diet with or without 1% GOS. To simulate intestinal barrier dysfunction, B6C3F₁ mice received a gavage with the mycotoxin deoxynivalenol (DON). To mimic asthma-like inflammatory airway responses, BALB/c mice were sensitized on day 0 and challenged on days 7-11 with house-dust mite (HDM) allergen. Samples from the intestines and lungs were collected for IL-33 and ST2 analysis by qRT-PCR, immunoblotting and immunohistochemistry. Results: Dietary GOS counteracted the DON-induced IL-33 mRNA expression and changed the IL-33 distribution pattern in the mouse small intestine. The IL-33 mRNA expression was positively correlated to the intestinal permeability. A strong positive correlation was also observed between IL-33 mRNA expression in the lung and the number of bronchoalveolar fluid cells. Reduced levels of IL-33 protein, altered IL-33 distribution and reduced ST2 mRNA expression were observed in the lungs of HDM-allergic mice after GOS intervention. Conclusions: Dietary GOS mitigated IL-33 at the mucosal surfaces in a murine model for intestinal barrier dysfunction and HDM-induced asthma. This promising effect may open up new avenues to use GOS not only as a prebiotic in infant nutrition, but also as a functional ingredient that targets inflammatory processes and allergies associated with IL-33 expression.

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“…ADAMTS12 gene is found in skeletal muscles, cartilage, tendons and fetal lung. [7][8][9] ADAMTS12 was shown to be associated with arthritis, 10 intervertebral disc degeneration, 11,12 inflammation, 13,14 tumor invasion, and metastasis. [15][16][17] Also, high levels of ADAMTS12 messenger ribonucleic acid (mRNA) were detected in osteoarthritis and rheumatoid arthritis.…”

mentioning

confidence: 99%

ADAMTS12 Depletion by Insulin in OUMS-27 Human Chondrosarcoma Cells

et al. 2015

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Objectives:In this study, we aim to investigate the association between articular damage in diabetes and a disintegrin-like and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) at gene expression and protein levels. Materials and methods: OUMS-27 human chondrosarcoma cells were used to investigate how ADAMTS12 levels changed in vitro condition in presence and absence of insulin. The study included three groups of cells treated with 10 μg/mL of insulin, and a control group. Cells were incubated with insulin in medium for one day, three days, and seven days. The effects of insulin on ADAMTS12 were investigated at both gene expression and protein levels. The relationships between the variables were tested by Mann-Whitney U test. Results: ADAMTS12 expression was significantly lower in the groups treated with insulin medium for one day and seven day periods (p=0.008 and p=0.008, respectively) compared to the control group. No significant difference was detected in the expression level between the groups kept in insulin medium for three days and the control group (p=0.55). In addition, protein amounts of the groups exposed to insulin medium for one, three, and seven day periods were lower. Conclusion: Insulin reduces the amount of ADAMTS12 which causes delayed recovery of cartilage tissue in the OUMS-27 cell lines utilized in our study for their chondrocytic properties. This reduction due to insulin treatment may contribute to recovery of cartilage tissue.

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Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12

Cited by 27 publications

References 62 publications

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Inflammation-Induced Expression of the Alarmin Interleukin 33 Can Be Suppressed by Galacto-Oligosaccharides

ADAMTS12 Depletion by Insulin in OUMS-27 Human Chondrosarcoma Cells

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