The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates

Guimaraes, Isabella M; Carvalho, Toniana G.; Ferguson, Stephen S. G.; Pereira, Grace Schenatto; Ribeiro, Fabíola M.

doi:10.1186/s13041-015-0113-2

Cited by 29 publications

(31 citation statements)

References 56 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Male C57BL/6N mice were obtained from Charles River Laboratories. Transgenic mice expressing an inducible CREB repressor (CREB IR mice) were backcrossed to C57BL/6 (Kida et al, 2002;Mamiya et al, 2009;Fukushima et al, 2014). The mice were housed in groups of five or six, maintained on a 12 h light/dark cycle, and allowed ad libitum access to food and water.…”

Section: Methodsmentioning

confidence: 99%

“…Social recognition task. The social recognition test was performed as described previously (Kogan et al, 2000;Suzuki et al, 2011;Ishikawa et al, 2014;Inaba et al, 2016b). Adult mice were placed into individual plastic cages in an experimental room under dim light.…”

Section: Methodsmentioning

confidence: 99%

“…CREB activates the expression of the immediate-early genes (IEGs) c-fos and Arc in an activity-and learning-dependent manner (Sheng et al, 1990;Abraham et al, 1993;Worley et al, 1993;Guzowski et al, 1999;Montag-Sallaz et al, 1999;Guthrie et al, 2000;Kaczmarek and Robertson, 2002;Kawashima et al, 2009). Importantly, abundant studies have shown that brain regions showing learning-induced IEG expression play essential roles in gene-expression-dependent memory processes including consolidation, reconsolidation, and extinction (Morrow et al, 1999;Santini et al, 2004;Mamiya et al, 2009;Fukushima et al, 2014). Therefore, the expression of IEGs has been widely accepted as a marker to identify brain regions that are activated in response to learning or memory retrieval (Guzowski et al, 2001;Frankland et al, 2004;Frankland et al, 2006;Mamiya et al, 2009;Fukushima et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, abundant studies have shown that brain regions showing learning-induced IEG expression play essential roles in gene-expression-dependent memory processes including consolidation, reconsolidation, and extinction (Morrow et al, 1999;Santini et al, 2004;Mamiya et al, 2009;Fukushima et al, 2014). Therefore, the expression of IEGs has been widely accepted as a marker to identify brain regions that are activated in response to learning or memory retrieval (Guzowski et al, 2001;Frankland et al, 2004;Frankland et al, 2006;Mamiya et al, 2009;Fukushima et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that multiple brain regions regulate social behaviors and the formation of social recognition memory. The hippocampus, amygdala, and anterior cingulate cortex (ACC) are critical regions for the formation/consolidation of social recognition memory in mice (Kogan et al, 2000;Suzuki et al, 2011, Hitti and Siegelbaum, 2014, Garrido Zinn et al, 2016. Conversely, the medial prefrontal cortex (mPFC) and amygdala are involved in the regulation of social behaviors such as social interaction and approach.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory

et al. 2017

View full text Add to dashboard Cite

Social recognition memory is an essential and basic component of social behavior that is used to discriminate familiar and novel animals/humans. Previous studies have shown the importance of several brain regions for social recognition memories; however, the mechanisms underlying the consolidation of social recognition memory at the molecular and anatomic levels remain unknown. Here, we show a brain network necessary for the generation of social recognition memory in mice. A mouse genetic study showed that cAMP-responsive element-binding protein (CREB)-mediated transcription is required for the formation of social recognition memory. Importantly, significant inductions of the CREB target immediate-early genes c-fos and Arc were observed in the hippocampus (CA1 and CA3 regions), medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and amygdala (basolateral region) when social recognition memory was generated. Pharmacological experiments using a microinfusion of the protein synthesis inhibitor anisomycin showed that protein synthesis in these brain regions is required for the consolidation of social recognition memory. These findings suggested that social recognition memory is consolidated through the activation of CREB-mediated gene expression in the hippocampus/mPFC/ACC/amygdala. Network analyses suggested that these four brain regions show functional connectivity with other brain regions and, more importantly, that the hippocampus functions as a hub to integrate brain networks and generate social recognition memory, whereas the ACC and amygdala are important for coordinating brain activity when social interaction is initiated by connecting with other brain regions. We have found that a brain network composed of the hippocampus/mPFC/ACC/amygdala is required for the consolidation of social recognition memory. Here, we identify brain networks composed of multiple brain regions for the consolidation of social recognition memory. We found that social recognition memory is consolidated through CREB-meditated gene expression in the hippocampus, medial prefrontal cortex, anterior cingulate cortex (ACC), and amygdala. Importantly, network analyses based on c-fos expression suggest that functional connectivity of these four brain regions with other brain regions is increased with time spent in social investigation toward the generation of brain networks to consolidate social recognition memory. Furthermore, our findings suggest that hippocampus functions as a hub to integrate brain networks and generate social recognition memory, whereas ACC and amygdala are important for coordinating brain activity when social interaction is initiated by connecting with other brain regions.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory

et al. 2017

View full text Add to dashboard Cite

show abstract

Motor behavior induced by bergamot essential oil in experimental tasks is differentially modulated by pretreatment with metabotropic glutamate receptor 2/3 or 5 antagonists

Rombolà,

De Rasis,

Sakurada

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Bergamot essential oil shows anxiolytic‐relaxant effects devoid of sedative action and motor impairment typical of benzodiazepines. Considering the potential for clinical of these effects, it is important to understand the underlying mechanisms of the phytocomplex. Modulation of glutamate group I and II metabotropic receptors is involved in stress and anxiety disorders, in cognition and emotions and increases locomotor activity and wakefulness. Interestingly, early data indicate that bergamot essential oil modulates glutamatergic transmission in specific manifestations of the central nervous system. The aim of this work is to investigate if selective antagonists of metabotropic glutamate 2/3 and 5 receptors affect behavioral parameters modulated by the phytocomplex. Male Wistar rats were used to measure behavioral parameters to correlate anxiety and motor activity using elevated plus maze (EPM), open field (OF), and rotarod tasks. Bergamot essential oil increases in EPM the time spent in open/closed arms and reduces total number of entries. The essential oil also increases immobility in EPM and OF and not affect motor coordination in rotarod. Pretreatment with the metabotropic glutamate antagonists does not affect the time spent in open/close arms, however, differently affects motor behavior measured after administration of phytocomplex. Particularly, glutamate 2/3 antagonist reverts immobility and glutamate 5 antagonist potentiates this parameter induced by the phytocomplex. Our data show that modulation of both metabotropic glutamate receptors is likely involved in some of behavioral effects of bergamot essential oil.

show abstract

mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity

Jew

Sun

et al. 2019

Psychopharmacology

View full text Add to dashboard Cite

Rationale-A role of group I metabotropic glutamate receptor 5 (mGlu5) in regulating spontaneous locomotion and psychostimulant-induced hyperactivity has been proposed.Objectives-This study aims to determine if mGlu5 in GABAergic neurons regulates spontaneous or psychostimulant-induced locomotion.Methods-We generated mice specifically lacking mGlu5 in forebrain GABAergic neuron by crossing DLX-Cre mice with mGlu5 flox/flox mice to generate DLX-mGlu5 KO mice. The locomotion of adult mice was examined in the open field assay (OFA) and home cage setting. The effects of the mGlu5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP), cocaine and methylphenidate on acute motor behaviors in DLX-mGlu5 KO and littermate control mice were assessed in OFA. Striatal synaptic plasticity of these mice was examined with field potential electrophysiological recordings.Results-Deleting mGlu5 from forebrain GABAergic neurons results in failure to induce longterm depression (LTD) in the dorsal striatum and absence of habituated locomotion in both novel and familiar settings. In a familiar environment (home cage), DLX-mGlu5 KO mice were hyperactive. In the OFA, DLX-mGlu5 KO mice exhibited initial hypo-activity, and then gradually increased their locomotion with time, resulting in no habituation response. DLX-mGlu5 KO mice

show abstract

The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates

Cited by 29 publications

References 56 publications

Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory

Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory

Motor behavior induced by bergamot essential oil in experimental tasks is differentially modulated by pretreatment with metabotropic glutamate receptor 2/3 or 5 antagonists

mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity

Contact Info

Product

Resources

About