mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity

Wu, Chia-Shan; Jew, Christopher P.; Sun, Hao; Rosado, Carlos J.; Lu, Hui-Chen

doi:10.1007/s00213-019-05367-0

Cited by 7 publications

(9 citation statements)

References 112 publications

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“…They reported genetic associations between genotypes and the grazing behaviours of home range and movement tortuosity, with a trend towards association with elevation range and horizontal distance travelled. These findings, together with the earlier study of Bailey et al ( 2015 ) and the reported associations of GRM5 expression variation with activity levels and exploratory behaviours in animal models (Bakker and Oostra 2003 ; Jew et al 2013 ; Wu et al 2020 ), support the relevance of GRM5 as a predictor of grazing personality behaviours in beef cattle.…”

Section: Introductionsupporting

confidence: 71%

“…The broad array of 35 variables were chosen based on their use in previous studies (Bailey and Provenza 2008 ; Bailey et al 2006 ; Browning et al 2018 ; Gillen et al 1984 ; Senft 1989 ; Senft et al 1983 ). Over the 15 consecutive days of GPS-based monitoring, the individual cow measurements were aggregated into daily mean values and coefficients of variation (CV) calculated using the ‘summary()’ function of ‘dplyr’ R package (Wickham et al 2021 ). Variables that were abnormally distributed were excluded from further analysis.…”

Section: Methodsmentioning

confidence: 99%

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Key Grazing Behaviours of Beef Cattle Identify Specific Genotypes of the Glutamate Metabotropic Receptor 5 Gene (GRM5)

Moreno García,

Perelman,

Dynes

et al. 2024

Behav Genet

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Genotype-phenotype associations between the bovine genome and grazing behaviours measured over time and across contexts have been reported in the past decade, with these suggesting the potential for genetic control over grazing personalities in beef cattle. From the large array of metrics used to describe grazing personality behaviours (GP-behaviours), it is still unclear which ones are linked to specific genes. Our prior observational study has reported associations and trends towards associations between genotypes of the glutamate metabotropic receptor 5 gene (GRM5) and four GP-behaviours, yet the unbalanced representation of GRM5 genotypes occurring in observational studies may have limited the ability to detect associations. Here, we applied a subsampling technique to create a genotypically-balanced dataset in a quasi-manipulative experiment with free ranging cows grazing in steep and rugged terrain of New Zealand’s South Island. Using quadratic discriminant analysis, two combinations of eleven GP-behaviours (and a total of fifteen behaviours) were selected to build an exploration model and an elevation model, respectively. Both models achieved ∼ 86% accuracy in correctly discriminating cows’ GRM5 genotypes with the training dataset, and the exploration model achieved 85% correct genotype prediction of cows from a testing dataset. Our study suggests a potential pleiotropic effect, with GRM5 controlling multiple grazing behaviours, and with implications for the grazing of steep and rugged grasslands. The study highlights the importance of grazing behavioural genetics in cattle and the potential use of GRM5 markers to select individuals with desired grazing personalities and built herds that collectively utilize steep and rugged rangelands sustainably.

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Section: Introductionsupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Key Grazing Behaviours of Beef Cattle Identify Specific Genotypes of the Glutamate Metabotropic Receptor 5 Gene (GRM5)

Moreno García,

Perelman,

Dynes

et al. 2024

Behav Genet

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“…Mobility was tested in a custom-made testing arena placed on the floor, with dimensions of 40 (length) × 40 (width) × 38 (height) cm. Mice were allowed to explore the arena freely for 10 min [ 26 , 27 , 28 ]. The experiment was video-recorded and tracked using ANY-maze software (Stoelting Co., Dublin, Ireland).…”

Section: Methodsmentioning

confidence: 99%

Prolonged Suppression of Neuropathic Hypersensitivity upon Neurostimulation of the Posterior Insula in Mice

Gan

Wang

et al. 2022

Cells

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Neurostimulation-based therapeutic approaches are emerging as alternatives to pharmacological drugs, but need further development to optimize efficacy and reduce variability. Despite its key relevance to pain, the insular cortex has not been explored in cortical neurostimulation approaches. Here, we developed an approach to perform repetitive transcranial direct current stimulation of the posterior insula (PI tDCS) and studied its impact on sensory and aversive components of neuropathic pain and pain-related anxiety and the underlying neural circuitry in mice using behavioral methods, pharmacological interventions and the expression of the activity-induced gene product, Fos. We observed that repetitive PI tDCS strongly attenuates the development of neuropathic mechanical allodynia and also reverses chronically established mechanical and cold allodynia for several weeks post-treatment by employing descending opioidergic antinociceptive pathways. Pain-related anxiety, but not pain-related aversion, were inhibited by PI tDCS. These effects were associated with a long-term suppression in the activity of key areas involved in pain modulation, such as the cingulate, prefrontal and motor cortices. These data uncover the significant potential of targeting the insular cortex with the objective of pain relief and open the way for more detailed mechanistic analyses that will contribute to improving cortical neurostimulation therapies for use in the clinical management of pain.

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“…In the behavioural context, Fu et al [64] illustrated that the effects of silent mutations on Drosophila circadian rhythm and thus, its potential implications on the regulation of animal daily and seasonal behaviours in general, which could apply Moreno García et al Journal of Animal Science and Biotechnology (2022) 13:111 to free-range cattle in steep and rugged terrain [65]. Considering the previously reported associations of GRM5 with behaviour, movement and cognitive abilities in several animal species [15,[17][18][19]21], the variants of bovine GRM5 reported here are notable, because of their potential for use in cattle selection programmes that could target particular grazing patterns and cattle distribution in rangelands.…”

Section: Variation In the Bovine Grm5 Genementioning

confidence: 99%

“…Jew's et al results showed direct association between GRM5 and locomotor reactivity to a novel environment, increased and decreased exploratory behaviour and, activity levels of mice. Subsequently, Wu et al [19] reported that GRM5 in the forebrain GABAergic neurons of mice modulated locomotor activity, and in this way it affected their horizontal and vertical distances travelled and the time spent moving. These authors reported that mice with genotypic variation in the glutamate metabotropic receptor 5 gene (GRM5) displayed different levels of activity in familiar and unfamiliar environments.…”

Section: Introductionmentioning

confidence: 99%

The glutamate metabotropic receptor 5 (GRM5) gene is associated with beef cattle home range and movement tortuosity

García

Zhou

Altimira³

et al. 2022

J Animal Sci Biotechnol

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Background The grazing behaviour of herbivores and their grazing personalities might in part be determined genetically, but there are few studies in beef cattle illustrating this. In this study, we investigated for first time the genetic variation within a candidate ‘grazing gene’, the glutamate metabotropic receptor 5 gene (GRM5), and tested associations between variation in that gene and variation in grazing personality behaviours (GP-behaviours) displayed by free-ranging cows during winter grazing in the steep and rugged rangelands of New Zealand. Mature beef cows (n = 303, from 3 to 10 years of age) were tracked with global positioning system (GPS) and, with 5-minutes (min) relocation frequency, various GP-behaviours were calculated. These included horizontal and vertical distances travelled, mean elevation, elevation range, elevation gain, slope, home range and movement tortuosity, variously calculated using daily relocation trajectories with repeated measurements (i.e., 7 to 24 days (d)) and satellite-derived digital elevation models (DEM). The different GP-behaviours were fitted into mixed models to ascertain their associations with variant sequences and genotypes of GRM5. Results We discovered three GRM5 variants (A, B and C) and identified the six possible genotypes in the cattle studied. The mixed models revealed that A was significantly associated with elevation range, home range and movement tortuosity. Similarly, GRM5 genotypes were associated (P < 0.05) to home range and movement tortuosity, while trends suggesting association (P < 0.1) were also revealed for elevation range and horizontal distance travelled. Most GP-behaviour models were improved by correcting for cow age-class as a fixed factor. The analysis of GP-behaviours averaged per cow age-class suggests that grazing personality is fully established as beef cows reached 4 years of age. Home range and movement tortuosity were not only associated with GRM5 variation, but also negatively correlated with each other (r = − 0.27, P < 0.001). Conclusions There seems to be a genetically determined trade-off between home range and movement tortuosity that may be useful in beef cattle breeding programmes aiming to improve the grazing distribution and utilisation of steep and rugged rangelands.

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mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity

Cited by 7 publications

References 112 publications

Key Grazing Behaviours of Beef Cattle Identify Specific Genotypes of the Glutamate Metabotropic Receptor 5 Gene (GRM5)

Key Grazing Behaviours of Beef Cattle Identify Specific Genotypes of the Glutamate Metabotropic Receptor 5 Gene (GRM5)

Prolonged Suppression of Neuropathic Hypersensitivity upon Neurostimulation of the Posterior Insula in Mice

The glutamate metabotropic receptor 5 (GRM5) gene is associated with beef cattle home range and movement tortuosity

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