The metabolism of neoplastic tissues

The Metabolism of Neoplastic Tissues: the Inter-relationship between Oxidative and Glycolytic Mechanisms in Ascites Tumour Cells

“…As might be expected, the incorporation of acetate-l-C14 into the long-chain fatty acids of the ascites cells was relatively poor in the absence, but markedly stimulated in the presence of glucose (Tables I and II). This stimulation is not characteristic of the ascites cells since it has been found also with many solid tumours (Emmelot and Bosch, 1955b;van Vals and Emmelot, 1957).…”

“…50 and 72 per cent respectively. This phenomenon has never been observed with any tumour of the solid type (Emmelot and Bosch, 1955b;van Vals and Emmelot, 1957). To see at which concentration of glucose the impairment in the incorporation of C14 into the proteins took place, two experiments were carried out with acetate-l-C14 and varying amounts of unlabelled glucose (19, 38, 75 and 113 ,umole) using the rhabdomyosarcoma cells.…”