The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study

Abstract

The effects of once daily MXR on chronic glycaemia, BMI, lipid profiles, insulin resistance and islet function are comparable with that of thrice daily MIR in oriental population.

Comparison of conventional and sustained-release formulation of metformin in type 2 diabetics

“…However, comparison between 2 groups did not show statistically significant difference (p=0.24). A 12 week randomized, open labelled, positive controlled multi centric study conducted by Gao H et al 26 showed significant reduction in metabolic parameters in both groups but no significance seen when 2 groups were compared, which is similar to findings from present study. Similarly one retrospective study conducted by Donnelly et al 22 and 6 month switched over study from MIR to MSR group conducted by Levy J et al 21 showed similar findings that metabolic parameters like weight and body mass index (BMI) showed no significant difference between MIR and MSR groups.…”

“…On comparing between 2 groups by unpaired t test, no statistically significant difference seen (p value 0.14). Results in present study matches with a multicentric study conducted by Gao H et al 26 which showed modest but significant decrease from baseline mean HbA1c in both MIR and MSR groups after 12 weeks of treatment, however there was no significant difference in mean HbA1c values observed between 2 groups at the end of 12 weeks treatment (p value 0.73). Similarly studies conducted by Levy J et al 21 and Bhansali A et al 25 showed comparable glycaemic control when patients were switched from immediate release formulation to sustained release formulation.…”

“…Similar findings were seen with a study conducted by Bhansali A 25 where switched from thrice daily immediate release formulation to once daily sustained released formulation at 3 months, showed no significant difference for TC, HDL, LDL and TG. A multicentric study conducted by Gao H et al 26 also showed no significant difference between any groups for lipid profile parameters.…”

“…Similar results were seen in study conducted by Bhansali A et al 25 which showed equal doses of 2 formulation MIR and MSR achieved comparable post prandial blood glucose level. However study conducted by Gao H et al 26 showed MSR given as a single evening dose of 1500 mg as compared to thrice daily doses of MIR 500 mg has weaker in reducing post prandial 120 min hyperglycaemia and that could be explained by the pharmacokinetic properties of MSR whose once daily dosing in the evening led to lower blood concentration of metformin in next morning than thrice daily dosing of MIR.…”

Safety, tolerability, and efficacy of metformin extended‐release oral antidiabetic therapy in patients with type 2 diabetes: An observational trial in Asia

“…Clinical studies in both predominantly Caucasian populations 25 and in Chinese patients with T2DM 29 have demonstrated that equivalent doses of MIR and MXR have similar antihyperglycemic efficacy. Further studies conducted in the US and UK have confirmed that among patients switched from MIR to comparable doses of MXR, the XR formulation has improved GI tolerability, with significantly fewer GI side‐effects; 24,30 glycemic efficacy in these studies was either equivalent or improved.…”