The metabolic effects of diuretics and other antihypertensive drugs: a perspective as of 1989

Raftery, Edward B.

doi:10.1016/0167-5273(90)90054-9

Cited by 11 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings of the current study are in line with the results of other authors (16)(17)(18)(19) , as they all found that calcium antagonists as a group have no significant effects on lipids. This study prospectively evaluated the impact of amlodipine, as a relatively new calcium channel blocker, on lipid profile in hypertensive patients, as this drug is increasingly used in clinical practice.…”

Section: Discussionsupporting

confidence: 93%

Effect of amlodipine on serum lipid profilein hypertensive patients

Al-Hayali¹,

Ahmed²

2009

Ann Coll Med Mosul

View full text Add to dashboard Cite

Objectives:To assess the effect of amlodipine, as monotherapy, in hypertensive patients, on serum lipid profile, as assessed by serum cholesterol, serum triglyceride, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC). Subjects and methods: Thirty three hypertensive patients were included in the study, 25 of them were males and 8 were females. Serum cholesterol, triglyceride, HDLC and LDLC were measured before and after 2 months of starting treatment with amlodipine. Results: No significant difference could be found between the pre and post treatment levels of all measured parameters. Conclusion: Treatment with amlodipine does not produce deleterious effect on lipid profile, so it may be a suitable therapy in a hypertensive patient with underlying hyperlipidaemia.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of amlodipine on serum lipid profilein hypertensive patients

Al-Hayali¹,

Ahmed²

2009

Ann Coll Med Mosul

View full text Add to dashboard Cite

show abstract

“…Every labeled and treated person is exposed to possible adverse consequences [19]. Electrolyte and metabolic disturbances are common, as is impotence [20], Moreover, it has been postulated, but not proved, that too great a drop in pressure (the J-shaped curve) may actually induce the myocardial infarction that treatment was prescribed to prevent [21,22]. All of these proved and postulated consequences of treatment have led some authorities to argue that the equivocal results of antihypertensive trials with regard to prevention of myocar dial infarction reflect the net result of heart attacks avoided minus the others caused by overzealous treatment [23], What about the failure to treat those many so-called normotensive persons who are at great absolute risk?…”

Section: Current Clinical Practicementioning

confidence: 99%

Absolute Cardiovascular Risk: The Basis for Deciding to Treat

Alderman

1996

Am J Nephrol

View full text Add to dashboard Cite

It has been convincingly demonstrated that raised blood pressure is a risk factor for cardiovascular disease and that its reduction saves lives. It seems logical to suggest that the whole population’s blood pressure distribution should be displaced downwards, since the reduction of blood pressure by only a few millimeters of mercury, if easily and safely achieved, would produce more disease prevention than could be attained by any other conceivable clinical strategy. Physicians already have powerful tools to lower blood pressure in individual patients, but must make challenging decisions as to when and how to use them. Blood pressure level is a reflection of relative risk and one of many risk factors that determine absolute risk. Reduction of blood pressure therefore does not cure cardiovascular disease, but reduces the risk of developing disease. The need for hypotensive therapy should be determined by absolute risk and the opportunity for successful prevention, rather than by a threshold level of blood pressure. The task of the physician is to assist the patient in assessing the balance between the potential for benefit and the burden of intervention, and to provide the best possible care to implement the therapeutic choice that is made.

show abstract

“…Esse fato pode estar relacionado à queda do metabolismo de glicose, levando à intolerância para esse nutriente, situação comum em idosos, tendo em vista as alterações resultantes do processo de envelhecimento (33, 105). 42 Ainda há que se considerar que os diuréticos são causadores de distúrbios do metabolismo de carboidratos (101). Assim, ainda que não tenha sido objetivo deste trabalho identificar os medicamentos utilizados pela população estudada pode-se supor que o uso de diuréticos é elevado.…”

Section: -----------------------_--_--__--------------------unclassified

Aspectos nutricionais e hábitos alimentares de idosos matriculados em ambulatório geriátrico

Marucci¹

View full text Add to dashboard Cite

Aspectos nutricionais RESUMOo presente estudo analisou aspectos nutricionais e hábitos alimentares de idosos, de ambos os sexos (69,8% mulheres e 30,2% homens), matriculados em ambulatório geriátrico, com idade variando de 60 a 100 anos (média e mediana igual a 74 anos).As variáveis sangüíneas, analisadas para 127 idosos, quando comparadas. com valores de referência, mostraram que a albumina, a HDL-C, a VLDL-C e os triglicérides apresentaram valores normais quanto à média para ambos os sexos, mas as duas primeiras ficaram abaixo desses valores e as duas últimas acima, em certo percentual de idosos quando consideradas segundo o sexo. A glicose, o colesterol e a LDL-C apresentaram valores acima dos de referência tanto na média quanto em certo número de idosos, quando separados por sexo.As medidas antropométricas, realizadas por nutricionistas treinadas, de acordo com metodologias previamente estabelecidas, foram analisadas também para 127 idosos e os resultados foram comparáveis aos de outros autores para peso e altura. A circunferência do braço apresentou-se excepcionalmente mais elevada nas mulheres do que nos homens. A prega cutânea triciptal e o índice de Quetelet são indicativos de obesidade, especialmente nas mulheres.o perfil de morbidade, estabelecido para 308 idosos, a partir dos diagnósticos registrados nos prontuários, revelou que a doença hipertensiva foi a mais prevalente, acometendo 49% dos indivíduos, seguida pelas doenças do sistema osteomuscular e tecido conjuntivo e pelas doenças endócrinas e metabólicas.A dieta habitual obtida em entrevista por nutricionistas treinadas, também em 308 idosos, mostrou que a freqüência de alimentos construtores e energéticos parece adequada, mas não a de reguladores e que os hábitos alimentares devem estar influenciando para a alteração de algumas variáveis sangüíneas.i i i SUMMARYThe present study analised the nutritional aspects and food habits of elderly persons, of both sexes (69.8% women and 30.2% men), registered at the geriatric out-patient service, with ages varying from 60 to 100 years (mean and median equal 74 years).

show abstract

The metabolic effects of diuretics and other antihypertensive drugs: a perspective as of 1989

Cited by 11 publications

References 55 publications

Effect of amlodipine on serum lipid profilein hypertensive patients

Effect of amlodipine on serum lipid profilein hypertensive patients

Absolute Cardiovascular Risk: The Basis for Deciding to Treat

Aspectos nutricionais e hábitos alimentares de idosos matriculados em ambulatório geriátrico

Contact Info

Product

Resources

About